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Background <p>There is&#xa0;a lack of established stent expansion criteria to predict long-term outcomes following percutaneous coronary intervention (PCI) in calcified coronary lesions.</p> Aims <p>The aim of this study was to evaluate the relationship between various stent expansion indices and clinical outcomes including target lesion failure (TLF) following PCI in patients with calcified coronary lesions.</p> Methods <p>This study was a retrospective single-center study. Patients with native&#xa0;calcified coronary artery&#xa0;lesions treated with imaging guided PCI and the availability of final intravascular ultrasound or optical coherence tomography images were included. The association between eight stent expansion indices and long-term TLF was evaluated.</p> Results <p>A total of 280 lesions from 221 patients were analyzed. The median patient age was 71&#xa0;years (Interquartile Range: 63–77), and 155 (70.1%) were male. Of the eight stent expansion indices, only the minimum stent area (MSA) &gt; 100% of distal reference lumen area (HR 0.29; 95% CI 0.13–0.65; <i>p</i> = 0.003), MSA &gt; 90% of distal reference area (HR 0.45; 95% CI 0.25–0.84; <i>p</i> = 0.012) and MSA &gt; 5.0 mm<sup>2</sup> or &gt; 90% of distal reference lumen area criteria (HR 0.41; 95% CI 0.22–0.75; <i>p</i> = 0.004) demonstrated a significant association with lower risk of long-term TLF.</p> Conclusions <p>In the present retrospective analysis, a final MSA &gt; 100% relative to the distal reference lumen area and MSA &gt; 5.0 mm<sup>2</sup> or &gt; 90% of distal reference lumen area criteria were most accurate in predicting TLF after PCI of calcified coronary lesions.</p> Graphical Abstract <p></p>

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Optimal Stent Expansion Indices for Predicting Outcomes in PCI of Calcified Coronary Lesions

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月17日

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  • Eleni Ntantou,
  • Alexandros A. Siskos,
  • William Camilleri,
  • Martin Roos,
  • Quinten Wolff,
  • Thomas Kok,
  • Isabella Kardys,
  • Joost Daemen,
  • Roberto Diletti,
  • Jeroen M. Wilschut,
  • Rutger-Jan Nuis,
  • Nicolas M. Van Mieghem,
  • Wijnand K. den Dekker

摘要

Background

There is a lack of established stent expansion criteria to predict long-term outcomes following percutaneous coronary intervention (PCI) in calcified coronary lesions.

Aims

The aim of this study was to evaluate the relationship between various stent expansion indices and clinical outcomes including target lesion failure (TLF) following PCI in patients with calcified coronary lesions.

Methods

This study was a retrospective single-center study. Patients with native calcified coronary artery lesions treated with imaging guided PCI and the availability of final intravascular ultrasound or optical coherence tomography images were included. The association between eight stent expansion indices and long-term TLF was evaluated.

Results

A total of 280 lesions from 221 patients were analyzed. The median patient age was 71 years (Interquartile Range: 63–77), and 155 (70.1%) were male. Of the eight stent expansion indices, only the minimum stent area (MSA) > 100% of distal reference lumen area (HR 0.29; 95% CI 0.13–0.65; p = 0.003), MSA > 90% of distal reference area (HR 0.45; 95% CI 0.25–0.84; p = 0.012) and MSA > 5.0 mm2 or > 90% of distal reference lumen area criteria (HR 0.41; 95% CI 0.22–0.75; p = 0.004) demonstrated a significant association with lower risk of long-term TLF.

Conclusions

In the present retrospective analysis, a final MSA > 100% relative to the distal reference lumen area and MSA > 5.0 mm2 or > 90% of distal reference lumen area criteria were most accurate in predicting TLF after PCI of calcified coronary lesions.

Graphical Abstract