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Background <p>Most initial experience with Left bundle branch are pacing (LBBAP) has involved lumenless leads (LLLs). Recently, stylet-driven leads (SDLs) have also been introduced for LBBAP. This study examined the clinical success rates, outcomes, and complication rates between SDLs and LLLs.</p> Methods and results <p>A systematic review of randomized clinical trials and observational studies comparing LLL and SDL up to November 30, 2024, was conducted. Random- and fixed-effects meta-analyses assessed the impact of implant technology on outcomes, including pacing metrics, lead complications, and procedural parameters. In total, 11 studies with 12,916 patients (SDLs: 3920; LLLs: 8996) were included. Implant success rates were comparable between SDL and LLL (RR 1.00, 95% CI 0.96–1.04, <i>P</i> = 0.96). SDL was associated with shorter procedure time (MD −&#xa0;11.94&#xa0;min, 95% CI −&#xa0;19.48 to −&#xa0;4.40, <i>P</i> = 0.002) and shorter fluoroscopy times, though this differences was not statistically significant (MD −&#xa0;1.27&#xa0;min, 95% CI −&#xa0;2.92 to 0.39, <i>P</i> = 0.13). Pacing metrics, including impedance, pacing threshold, and R-wave amplitude, also showed no significant differences during follow-up (up to 28&#xa0;months). However, SDLs were associated with a significantly higher risk of lead-related complications compared to LLLs (RR 1.89, 95% CI 1.47–2.41, <i>P</i> &lt; 0001).</p> Conclusion <p>LBBAP using SDL is feasible and demonstrates comparable success rates with a shorter procedure duration. A higher incidence of lead-related complications was observed in the SDL group; however, due to potential confounding factors and the absence of randomized head-to-head comparisons, no definitive conclusions can be drawn regarding causality. Further prospective studies are warranted to clarify this association. </p> Graphical Abstract <p></p>

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Outcomes of stylet-driven leads compared to lumenless leads for left bundle branch are pacing: systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月15日

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  • Amr Abdin,
  • Haran Burri,
  • Guram Imnadze,
  • Khaled Turkmani,
  • Hussam Al Ghorani,
  • Alhasan Almasri,
  • Christian Werner,
  • Saarraaken Kulenthiran

摘要

Background

Most initial experience with Left bundle branch are pacing (LBBAP) has involved lumenless leads (LLLs). Recently, stylet-driven leads (SDLs) have also been introduced for LBBAP. This study examined the clinical success rates, outcomes, and complication rates between SDLs and LLLs.

Methods and results

A systematic review of randomized clinical trials and observational studies comparing LLL and SDL up to November 30, 2024, was conducted. Random- and fixed-effects meta-analyses assessed the impact of implant technology on outcomes, including pacing metrics, lead complications, and procedural parameters. In total, 11 studies with 12,916 patients (SDLs: 3920; LLLs: 8996) were included. Implant success rates were comparable between SDL and LLL (RR 1.00, 95% CI 0.96–1.04, P = 0.96). SDL was associated with shorter procedure time (MD − 11.94 min, 95% CI − 19.48 to − 4.40, P = 0.002) and shorter fluoroscopy times, though this differences was not statistically significant (MD − 1.27 min, 95% CI − 2.92 to 0.39, P = 0.13). Pacing metrics, including impedance, pacing threshold, and R-wave amplitude, also showed no significant differences during follow-up (up to 28 months). However, SDLs were associated with a significantly higher risk of lead-related complications compared to LLLs (RR 1.89, 95% CI 1.47–2.41, P < 0001).

Conclusion

LBBAP using SDL is feasible and demonstrates comparable success rates with a shorter procedure duration. A higher incidence of lead-related complications was observed in the SDL group; however, due to potential confounding factors and the absence of randomized head-to-head comparisons, no definitive conclusions can be drawn regarding causality. Further prospective studies are warranted to clarify this association.

Graphical Abstract