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Purpose <p>To evaluate and compare short-term and two-year outcomes, particularly aspiration pneumonia-free survival, after fundoplication in pediatric patients with and without cerebral palsy (CP).</p> Method <p>The study reviewed outcomes after fundoplication in pediatric patients performed between 2004 and 2025 at a university hospital in Thailand, focusing on aspiration pneumonia-free survival. Statistical analyses used log-rank test and Cox proportional hazards model.</p> Results <p>During the study, 85 cases underwent surgery. Diagnoses included gastroesophageal reflux (84.7%) and hiatal hernia (10.9%). Forty-five cases (52.9%) had CP, with significantly higher rates of co-occurring epilepsy (OR 33.9) and recurrent pneumonia (OR 3.6). Post-procedure, first-year pneumonia episodes were similar (median 0 occurrence in the CP group and 0.5 occurrence in the non-CP, <i>p</i> = 0.473). The mean interval to first pneumonia was longer in CP (418 days) than in non-CP (209 days, <i>p</i> = 0.049). One-year overall survival was 69.6%. One-year pneumonia-free survival in CP (50.4%) did not differ from non-CP (51.5%, <i>p</i> = 0.29).</p> Conclusion <p>Despite a higher comorbidity burden and nutritional support needs, fundoplication outcomes in pediatric patients with CP were comparable to those without CP. These findings suggest fundoplication is an equally effective and safe surgical option for anti-reflux management in pediatric patients with CP.</p>

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Do pediatric patients with cerebral palsy have worse outcomes after anti-reflux esophageal surgery?

  • 期刊论文

  • 发表日期：

    2026年6月15日

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  • Sasabong Tiyaamornwong,
  • Kulpreeya Sirichamratsakul,
  • Piyawan Chiengkriwate,
  • Atchariya Chanpong,
  • Surasak Sangkhathat

摘要

Purpose

To evaluate and compare short-term and two-year outcomes, particularly aspiration pneumonia-free survival, after fundoplication in pediatric patients with and without cerebral palsy (CP).

Method

The study reviewed outcomes after fundoplication in pediatric patients performed between 2004 and 2025 at a university hospital in Thailand, focusing on aspiration pneumonia-free survival. Statistical analyses used log-rank test and Cox proportional hazards model.

Results

During the study, 85 cases underwent surgery. Diagnoses included gastroesophageal reflux (84.7%) and hiatal hernia (10.9%). Forty-five cases (52.9%) had CP, with significantly higher rates of co-occurring epilepsy (OR 33.9) and recurrent pneumonia (OR 3.6). Post-procedure, first-year pneumonia episodes were similar (median 0 occurrence in the CP group and 0.5 occurrence in the non-CP, p = 0.473). The mean interval to first pneumonia was longer in CP (418 days) than in non-CP (209 days, p = 0.049). One-year overall survival was 69.6%. One-year pneumonia-free survival in CP (50.4%) did not differ from non-CP (51.5%, p = 0.29).

Conclusion

Despite a higher comorbidity burden and nutritional support needs, fundoplication outcomes in pediatric patients with CP were comparable to those without CP. These findings suggest fundoplication is an equally effective and safe surgical option for anti-reflux management in pediatric patients with CP.