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Objective <p>To identify risk factors for conversion to open surgery during laparoscopic choledochal cyst excision in pediatric patients and develop a predictive model using machine learning.</p> Methods <p>We retrospectively analyzed 214 children who underwent laparoscopic excision between 2015 and 2023. Patients were classified into laparoscopic (<i>n</i> = 173) or conversion (<i>n</i> = 41) groups. Seven machine learning models were developed and evaluated using AUC and decision curve analysis (DCA). SHAP analysis identified top predictors, which were validated via multivariable logistic regression. A nomogram was constructed and internally validated for discrimination, calibration, and clinical utility.</p> Results <p>GBM performed best (AUC = 0.897) with the highest net benefit on DCA. SHAP highlighted age, cyst wall thickening (≥ 3&#xa0;mm), obstructive jaundice, cyst diameter, ALT, and history of perforation. Multivariable analysis confirmed age (OR = 1.022, 95% CI 1.01–1.04; <i>P</i> = 0.004), cyst wall thickening (OR = 15.024, 95% CI 5.03–49.48; <i>P</i> &lt; 0.001), and obstructive jaundice (OR = 10.933, 95% CI 2.76–49.28; <i>P</i> = 0.001) as independent predictors. The nomogram achieved a C-index of 0.843 (95% CI 0.814–0.872), showed good calibration (<i>P</i> = 0.318), and demonstrated consistent performance in cross-validation and DCA. The optimal age cutoff was 27.5 months.</p> Conclusion <p>Age &gt; 27.5 months, cyst wall thickening, and obstructive jaundice are key predictors of conversion. The nomogram provides a clinically useful tool for preoperative risk stratification, pending external validation.</p>

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Machine learning-based prediction model for risk factors associated with conversion to open surgery in pediatric laparoscopic radical resection of choledochal cysts

  • 期刊论文

  • 发表日期：

    2026年4月3日

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  • Yue Wang,
  • Xiaohan Wu,
  • Ting Xu,
  • Jiangbin Liu,
  • Zhibao Lv,
  • Guogang Ye

摘要

Objective

To identify risk factors for conversion to open surgery during laparoscopic choledochal cyst excision in pediatric patients and develop a predictive model using machine learning.

Methods

We retrospectively analyzed 214 children who underwent laparoscopic excision between 2015 and 2023. Patients were classified into laparoscopic (n = 173) or conversion (n = 41) groups. Seven machine learning models were developed and evaluated using AUC and decision curve analysis (DCA). SHAP analysis identified top predictors, which were validated via multivariable logistic regression. A nomogram was constructed and internally validated for discrimination, calibration, and clinical utility.

Results

GBM performed best (AUC = 0.897) with the highest net benefit on DCA. SHAP highlighted age, cyst wall thickening (≥ 3 mm), obstructive jaundice, cyst diameter, ALT, and history of perforation. Multivariable analysis confirmed age (OR = 1.022, 95% CI 1.01–1.04; P = 0.004), cyst wall thickening (OR = 15.024, 95% CI 5.03–49.48; P < 0.001), and obstructive jaundice (OR = 10.933, 95% CI 2.76–49.28; P = 0.001) as independent predictors. The nomogram achieved a C-index of 0.843 (95% CI 0.814–0.872), showed good calibration (P = 0.318), and demonstrated consistent performance in cross-validation and DCA. The optimal age cutoff was 27.5 months.

Conclusion

Age > 27.5 months, cyst wall thickening, and obstructive jaundice are key predictors of conversion. The nomogram provides a clinically useful tool for preoperative risk stratification, pending external validation.