Scholarlink

Purpose <p>To evaluate the impact of IDRFs on surgical outcomes, complications, and survival in abdominal neuroblastoma (ANB).</p> Method <p>Retrospective study of patients (&lt; 15 years) with ANB stage L2 or higher treated over two decades at a university centre in Thailand.</p> Results <p>Among fifty patients, 94% had high-risk neuroblastoma. Preoperative tumour encasement of the celiac axis (CA) or origin of SMA was more frequent in incomplete resection (33% vs. 9%, <i>p</i> = 0.04). Complications were greater in children with abdominal aorta/IVC tumour encasement (58% vs. 27%, <i>p</i> &lt; 0.03) and adjacent organ infiltrative tumours (42% vs. 7%, <i>p</i> &lt; 0.04). Visceral organ injuries correlated with vascular/infiltrating IDRFs. Tumours invading CA/SMA carried less risk (%) of vascular injury (<i>r</i> =- 0.28, <i>p</i> = 0.04). Only tumour encasement of the SMA at the mesenteric root predicted disease progression (<i>r</i> = 0.35, <i>p</i> = 0.01). Incomplete resection was associated with higher risks (%) of disease progression. Two- and five-year survival rates were 80.6% and 52.1%, respectively.</p> Conclusion <p>Vascular IDRFs especially mesenteric root encasement were linked to risk of visceral organ injury and disease progression. Awareness of <i>risks</i> may reduce vascular injury during operation though incomplete resection influenced disease progression. Survival outcomes are comparable to Southeast Asia Regions.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Image defined risk factor(s) and outcomes for abdominal neuroblastoma: a surgical perspective from a Thailand National Cancer Centre

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月11日

查看全文
  • Bhavita Thamsopitt,
  • Thitiporn Junhasavasdikul,
  • Suwadee Eng-Chaun,
  • Paul D. Losty,
  • Pornsri Thanachatchairattana

摘要

Purpose

To evaluate the impact of IDRFs on surgical outcomes, complications, and survival in abdominal neuroblastoma (ANB).

Method

Retrospective study of patients (< 15 years) with ANB stage L2 or higher treated over two decades at a university centre in Thailand.

Results

Among fifty patients, 94% had high-risk neuroblastoma. Preoperative tumour encasement of the celiac axis (CA) or origin of SMA was more frequent in incomplete resection (33% vs. 9%, p = 0.04). Complications were greater in children with abdominal aorta/IVC tumour encasement (58% vs. 27%, p < 0.03) and adjacent organ infiltrative tumours (42% vs. 7%, p < 0.04). Visceral organ injuries correlated with vascular/infiltrating IDRFs. Tumours invading CA/SMA carried less risk (%) of vascular injury (r =- 0.28, p = 0.04). Only tumour encasement of the SMA at the mesenteric root predicted disease progression (r = 0.35, p = 0.01). Incomplete resection was associated with higher risks (%) of disease progression. Two- and five-year survival rates were 80.6% and 52.1%, respectively.

Conclusion

Vascular IDRFs especially mesenteric root encasement were linked to risk of visceral organ injury and disease progression. Awareness of risks may reduce vascular injury during operation though incomplete resection influenced disease progression. Survival outcomes are comparable to Southeast Asia Regions.