Scholarlink

Purpose <p>This study aims to explore maternal and pregnancy-related risk factors for colonic atresia (CA) and assess the national total prevalence, mortality, and frequency of co-occurring anomalies of this rare malformation in 2004–2017.</p> Methods <p>This case-control study involved 36 cases with congenital CA identified from several Finnish registers. All cases were identified based on the ICD-9/ICD-10 codes and classified based on co-occurring anomalies. Five controls without gastrointestinal congenital malformations matched for residence and time of conception (± 1 year) were randomly selected for each case. Maternal risk factors were analyzed with data from the same registers.</p> Results <p>Total prevalence of CA was 0.45/10,000, birth prevalence was 0.37/10,000 and live birth prevalence was 0.36/10,000. The overall prevalence trend did not change (<i>p</i> = 0.11) during the study period. There were 15 (41.7%) isolated cases, 3 (8.3%) were associated with known syndromes and 18 (50.0%) had multiple congenital anomalies. Together there were 19.4% (<i>n</i> = 7) terminations or neonatal mortalities. An association was observed with maternal diabetes and CA (<i>p</i> = 0.03).</p> Conclusion <p>The prevalence of CA in Finland is low with no significant change over the study period. Despite the high frequency of associated anomalies, the overall survival of CA is very high, 97%.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prevalence, risk factors and mortality associated with colonic atresia: a population-based case-control study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月23日

查看全文
  • Roni Kankaristo,
  • Ilkka Helenius,
  • Susanna Heiskanen,
  • Johanna Syvänen,
  • Teemu Kemppainen,
  • Eliisa Löyttyniemi,
  • Mika Gissler,
  • Arimatias Raitio

摘要

Purpose

This study aims to explore maternal and pregnancy-related risk factors for colonic atresia (CA) and assess the national total prevalence, mortality, and frequency of co-occurring anomalies of this rare malformation in 2004–2017.

Methods

This case-control study involved 36 cases with congenital CA identified from several Finnish registers. All cases were identified based on the ICD-9/ICD-10 codes and classified based on co-occurring anomalies. Five controls without gastrointestinal congenital malformations matched for residence and time of conception (± 1 year) were randomly selected for each case. Maternal risk factors were analyzed with data from the same registers.

Results

Total prevalence of CA was 0.45/10,000, birth prevalence was 0.37/10,000 and live birth prevalence was 0.36/10,000. The overall prevalence trend did not change (p = 0.11) during the study period. There were 15 (41.7%) isolated cases, 3 (8.3%) were associated with known syndromes and 18 (50.0%) had multiple congenital anomalies. Together there were 19.4% (n = 7) terminations or neonatal mortalities. An association was observed with maternal diabetes and CA (p = 0.03).

Conclusion

The prevalence of CA in Finland is low with no significant change over the study period. Despite the high frequency of associated anomalies, the overall survival of CA is very high, 97%.