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Background <p>Pediatric spinal injuries refers to a medical condition characterized by structural or functional impairment of the spinal cord in children, resulting from trauma, infections, or other etiological factors, which may lead to severe consequences such as paraplegia or quadriplegia.​</p> Methods <p>Epidemiological data on subtypes of spinal injuries in children were sourced from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, encompassing annual estimates from 1990 to 2021. We analyzed the disease burden and epidemiological trends of distinct spinal injuries subtypes in children. Using the nordpred model, we projected the global burden of pediatric spinal injuries through 2046.</p> Result <p>n 2021, the global incidence of pediatric spinal injury cases was 72,628 (55,829–94,283), including pediatric spinal cord lesion at neck level with 34,695 (25,206–49,063) incidence cases, and pediatric spinal cord lesion below neck level with 37,933 (27,349–51,354) incidence cases. The global ASIR of pediatric spinal injury cases was 3.60(2.70–4.83), including pediatric spinal cord lesion at neck level with an ASIR of 1.72(1.20–2.50), and pediatric spinal cord lesion below neck level with an ASIR of 1.88(1.30–2.71). The global prevalence of pediatric spinal injury cases was 593,486 (521,155–683,457) and the global ASPR of pediatric spinal injury cases was 28.65(24.88–33.18). The global Years Lived with Disability (YLDs) due to pediatric spinal injuries was 199,941 (139,710–265,960), and the global ASYR of pediatric spinal injury cases was 9.66(6.65–12.94). Based on Joinpoint Regression analysis, we found that from 1990 to 2021, the Average Annual Percent Change (AAPC) in the ASIR of Global Pediatric Spinal Injuries was − 1.4(-1.73 to -1.07)). The AAPC for the ASPR of Global Pediatric Spinal Injuries was − 1.32(-1.36 to -1.27). The AAPC for the ASYR of Global Pediatric Spinal Injuries was − 1.58(-1.62 to -1.52).Based on the Nordpred model, it is projected that by 2046, the global number of new pediatric spinal injuries cases would be 57,877 with an ASIR of 3.13. The global number of pediatric spinal injuries prevalent cases would be 472,447 with an ASPR of 24.69. The global YLDs from pediatric spinal injuries would be 153,221 with an ASYR of 8.01.</p> Conclusion <p>The global epidemiological curve of pediatric spinal injury incidence is trending downward, yet these injuries still impose severe YLDs and high prevalence worldwide.</p>

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The global burden of pediatric spinal injury: an epidemiological analysis across injury subtypes in children under 14 years

  • 期刊论文

  • 发表日期：

    2025年12月16日

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  • Zhenzhong Zeng,
  • Kaibin Fang,
  • Gangfeng Cai

摘要

Background

Pediatric spinal injuries refers to a medical condition characterized by structural or functional impairment of the spinal cord in children, resulting from trauma, infections, or other etiological factors, which may lead to severe consequences such as paraplegia or quadriplegia.​

Methods

Epidemiological data on subtypes of spinal injuries in children were sourced from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, encompassing annual estimates from 1990 to 2021. We analyzed the disease burden and epidemiological trends of distinct spinal injuries subtypes in children. Using the nordpred model, we projected the global burden of pediatric spinal injuries through 2046.

Result

n 2021, the global incidence of pediatric spinal injury cases was 72,628 (55,829–94,283), including pediatric spinal cord lesion at neck level with 34,695 (25,206–49,063) incidence cases, and pediatric spinal cord lesion below neck level with 37,933 (27,349–51,354) incidence cases. The global ASIR of pediatric spinal injury cases was 3.60(2.70–4.83), including pediatric spinal cord lesion at neck level with an ASIR of 1.72(1.20–2.50), and pediatric spinal cord lesion below neck level with an ASIR of 1.88(1.30–2.71). The global prevalence of pediatric spinal injury cases was 593,486 (521,155–683,457) and the global ASPR of pediatric spinal injury cases was 28.65(24.88–33.18). The global Years Lived with Disability (YLDs) due to pediatric spinal injuries was 199,941 (139,710–265,960), and the global ASYR of pediatric spinal injury cases was 9.66(6.65–12.94). Based on Joinpoint Regression analysis, we found that from 1990 to 2021, the Average Annual Percent Change (AAPC) in the ASIR of Global Pediatric Spinal Injuries was − 1.4(-1.73 to -1.07)). The AAPC for the ASPR of Global Pediatric Spinal Injuries was − 1.32(-1.36 to -1.27). The AAPC for the ASYR of Global Pediatric Spinal Injuries was − 1.58(-1.62 to -1.52).Based on the Nordpred model, it is projected that by 2046, the global number of new pediatric spinal injuries cases would be 57,877 with an ASIR of 3.13. The global number of pediatric spinal injuries prevalent cases would be 472,447 with an ASPR of 24.69. The global YLDs from pediatric spinal injuries would be 153,221 with an ASYR of 8.01.

Conclusion

The global epidemiological curve of pediatric spinal injury incidence is trending downward, yet these injuries still impose severe YLDs and high prevalence worldwide.