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Objective <p>To investigate the predictive value of the aspartate aminotransferase-to-platelet ratio index (APRI) in combination with liver biochemical indices on the time to native liver survival (NLS) in patients with biliary atresia (BA) two years after Kasai portoenterostomy (KPE).</p> Methods <p>The clinical data from 2013 to 2022 at Shanxi Children's Hospital were analyzed. Patients were divided into two groups based on whether they survived with their native liver 2&#xa0;years after KPE. General information and laboratory findings were reviewed before and then monthly after KPE until 3&#xa0;months postoperatively. APRI was calculated.</p> Results <p>A total of 125 children with type III BA were included. There were statistically significant differences in the preoperative AST, GGT, APRI, liver fibrosis stage and jaundice clearance rate between two groups. The AUC of APRI at 3&#xa0;months for predicting NLS was 0.732. The AUC of APRI at 3&#xa0;months in predicting the 2-year NLS time in children with BA was higher than the single index.</p> Conclusion <p>The prediction value of APRI for 2-year NLS time increases when combined with other indicators, and is better than single indicator, the prediction value is strongest when APRI is combined with all indicators.</p>

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The predictive value of the aspartate aminotransferase to platelet ratio index combined with liver biochemical indexes for 2 years native liver survival in patients with biliary atresia

  • 期刊论文

  • 发表日期：

    2025年2月26日

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  • Bingliang Li,
  • Yingyu Jia,
  • Hongwei Xi,
  • Hongxia Ren

摘要

Objective

To investigate the predictive value of the aspartate aminotransferase-to-platelet ratio index (APRI) in combination with liver biochemical indices on the time to native liver survival (NLS) in patients with biliary atresia (BA) two years after Kasai portoenterostomy (KPE).

Methods

The clinical data from 2013 to 2022 at Shanxi Children's Hospital were analyzed. Patients were divided into two groups based on whether they survived with their native liver 2 years after KPE. General information and laboratory findings were reviewed before and then monthly after KPE until 3 months postoperatively. APRI was calculated.

Results

A total of 125 children with type III BA were included. There were statistically significant differences in the preoperative AST, GGT, APRI, liver fibrosis stage and jaundice clearance rate between two groups. The AUC of APRI at 3 months for predicting NLS was 0.732. The AUC of APRI at 3 months in predicting the 2-year NLS time in children with BA was higher than the single index.

Conclusion

The prediction value of APRI for 2-year NLS time increases when combined with other indicators, and is better than single indicator, the prediction value is strongest when APRI is combined with all indicators.