Efforts to improve outcomes among neonates with complex intestinal atresia: a single-center low-income country experience

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2024年3月6日

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Innocent Okello,
Caroline Q. Stephens,
Nasser Kakembo,
Phyllis Kisa,
Stella Nimanya,
Ava Yap,
Anne S. Wesonga,
Rovine Naluyimbazi,
Peter Kayima,
Yasin Ssewanyana,
Doruk Ozgediz,
John Sekabira

摘要

Purpose

Intestinal obstruction caused by intestinal atresia is a surgical emergency in newborns. Outcomes for the jejunal ileal atresia (JIA), the most common subtype of atresia in low-income countries (LIC), are poor. We sought to assess the impact of utilizing the Bishop–Koop (BK) approach to JIA in improving outcomes.

Methods

A retrospective cohort study was performed on children with complex JIA (Type 2–4) treated at our national referral hospital from 1/2018 to 12/2022. BK was regularly used starting 1/1/2021, and outcomes between 1/2021 and 12/2022 were compared to those between 1/2018 and 12/2020. Statistical significance was set at p < 0.05.

Results

A total of 122 neonates presented with JIA in 1/2018–12/2022, 83 of whom were treated for complex JIA. A significant decrease (p = 0.03) was noted in patient mortality in 2021 and 2022 (n = 33, 45.5% mortality) compared to 2018–2020 (n = 35, 71.4% mortality). This translated to a risk reduction of 0.64 (95% CI 0.41–0.98) with the increased use of BK.

Conclusion

Increased use of BK anastomoses with early enteral nutrition and decreased use of primary anastomosis improves outcomes for neonates with severe JIA in LIC settings. Implementing this surgical approach in LICs may help address the disparities in outcomes for children with JIA.