<p>Glaciers on the&#xa0;Tibetan Plateau (TP) are retreating rapidly in response to global warming. While extensive research has focused on the spatial heterogeneity of glacier retreat across the TP, only a few studies have examined the role of TP lakes in shaping these patterns. In this study, we applied the Weather Research and Forecasting (WRF) model, coupled with a one-dimensional lake mass and energy balance scheme, to examine how TP lakes affect seasonal surface air temperature, snowfall, and water vapor flux, and how these lake-induced climatic changes influence the spatial heterogeneity and seasonal variability of glacier retreat across the region. Results show that TP lakes tend to reduce 2-m air temperature (T_2m) in glacierized regions in many seasons, and are associated with increased snowfall on some alpine glaciers in the Inner TP during summer and autumn, and on marginal glaciers during winter and spring. Furthermore, the seasonal climate effects of individual lakes vary regionally, and they may exert distinct influences on adjacent glaciers, particularly in autumn in our simulations. Langa Co and Mapam Yumco may contribute to reduced T_2m and enhanced snowfall over the Naimona’nyi Glacier to the south, which is consistent with the relatively slower retreat observed among glaciers in the West Himalayas. Similarly, Yamzho Yumco and Puma Yumco have comparable impacts on the Qiangyong Glacier in the Central Himalayas. Additionally, Nam Co exerts contrasting influences on the western Nyainqentanglha Range, mitigating glacier retreat on the southern slopes but intensifying it on the northern slopes during summer, with the opposite pattern occurring in autumn. Simulations indicate that TP lakes can modify regional moisture pathways, contributing to enhanced northward water vapor fluxes associated with the Indian Summer Monsoon in some cases, which may influence snowfall and glacier mass balance in regions such as the West Kunlun and Tanggula Mountains.</p>