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Aim <p>This study aimed to identify factors influencing brain volumes at term-equivalent age (TEA) in preterm infants with post-haemorrhagic ventricular dilatation (PHVD) and explore how these volumes, and other factors, correlate with neurodevelopmental outcome (NDO).</p> Method <p>A retrospective cohort study of 84 infants with PHVD managed on a standardised pathway at a single centre between 2012 and 2020.</p> <p>Brain volumes were measured from TEA MRI scans in 31 infants. NDO was assessed at one and two years. Primary analyses included the 31 infants with measured brain volumes. Sensitivity analysis included all 84 infants using multiple imputation for missing brain volumes.</p> Results <p>Sepsis (-12.75mL, 95% CI -17.89 to -7.61) was linked to smaller cerebellar volume. Intubation (-0.09mL/day, 95% CI -0.15 to -0.04) and inotropic support (-3.19mL, 95% CI -6.18 to -0.20) were associated with reduced deep grey matter (dGM) volume. Larger dGM volume predicted lower odds of poor NDO at two years (OR 0.75, 95% CI 0.60 to 0.94). Sensitivity analysis supported these findings.</p> Interpretation <p>dGM volume at TEA could predict NDO among infants with PHVD. Addressing modifiable factors influencing dGM volume may improve outcomes.</p> <p>Understanding associations of independent variables with NDO is essential to evaluate the impact of neurosurgical interventions.</p> What this paper adds <p>- Among infants with post-haemorrhagic ventricular dilatation:</p> <p>- Sepsis was associated with smaller cerebellar volumes at term-equivalent age.</p> <p>- Intubation and inotrope use were associated with smaller deep grey matter volumes at term-equivalent age.</p> <p>- Larger deep grey matter volume at term-equivalent age was associated with improved neurodevelopmental outcome at two years.</p>

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Volumetric analysis of term-equivalent age MRI in post-haemorrhagic ventricular dilatation reveals association between deep grey matter volume and developmental outcomes

  • 期刊论文

  • 发表日期：

    2025年11月24日

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  • Matthew John Kane,
  • Jonathan O’Muircheartaigh,
  • Malak Mohamed,
  • Kshitij Mankad,
  • Cristine Sortica Da Costa,
  • William Dawes,
  • Greg James,
  • Aswin Chari,
  • Kristian Aquilina

摘要

Aim

This study aimed to identify factors influencing brain volumes at term-equivalent age (TEA) in preterm infants with post-haemorrhagic ventricular dilatation (PHVD) and explore how these volumes, and other factors, correlate with neurodevelopmental outcome (NDO).

Method

A retrospective cohort study of 84 infants with PHVD managed on a standardised pathway at a single centre between 2012 and 2020.

Brain volumes were measured from TEA MRI scans in 31 infants. NDO was assessed at one and two years. Primary analyses included the 31 infants with measured brain volumes. Sensitivity analysis included all 84 infants using multiple imputation for missing brain volumes.

Results

Sepsis (-12.75mL, 95% CI -17.89 to -7.61) was linked to smaller cerebellar volume. Intubation (-0.09mL/day, 95% CI -0.15 to -0.04) and inotropic support (-3.19mL, 95% CI -6.18 to -0.20) were associated with reduced deep grey matter (dGM) volume. Larger dGM volume predicted lower odds of poor NDO at two years (OR 0.75, 95% CI 0.60 to 0.94). Sensitivity analysis supported these findings.

Interpretation

dGM volume at TEA could predict NDO among infants with PHVD. Addressing modifiable factors influencing dGM volume may improve outcomes.

Understanding associations of independent variables with NDO is essential to evaluate the impact of neurosurgical interventions.

What this paper adds

- Among infants with post-haemorrhagic ventricular dilatation:

- Sepsis was associated with smaller cerebellar volumes at term-equivalent age.

- Intubation and inotrope use were associated with smaller deep grey matter volumes at term-equivalent age.

- Larger deep grey matter volume at term-equivalent age was associated with improved neurodevelopmental outcome at two years.