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<p>In patients with manifest Wolff–Parkinson–White syndrome (WPWS), the ventricles are electrically and mechanically pre-excited via an accessory pathway (AP; left-sided AP: type A, right-sided AP: type B). Left ventricular (LV) dyssynchrony contributes to LV dysfunction. Although left atrial (LA) function is recognized as a sensitive indicator of clinical outcomes in various diseases, there have been no reports on LA function in pediatric patients with WPWS. We measured LA and LV strain and dyssynchrony indices in patients with WPWS (W-group: 36 participants) and normal controls (N-group: 41 participants) categorized by age (Group 1 ≦ 11 years, Group 2 ≧ 12 years). LA reservoir strain (LASr) in the W group was significantly lower than those in the N group in both age groups. LASr showed weak to moderate correlation with LV dyssynchrony index in Group 1 and with LV strain in Group 2. No significant differences were observed in LASr between types A and B within each age group. In Group 1, the LV longitudinal strain (LVLS) of type B was significantly lower than that in the N group. In Group 2, LVLS in both types was lower than that in the N group. The location of AP did not significantly impact LA dysfunction, which primarily correlated with LV dyssynchrony in younger patients and LV dysfunction in older patients. LA dyssynchrony was observed in both age groups. LA phasic strain may serve as an early indicator of cardiac dysfunction.</p>

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Left atrium dysfunction and dyssynchrony in pediatric patients with Wolff–Parkinson–White syndrome assessed using speckle-tracking echocardiography

  • 期刊论文

  • 发表日期：

    2026年4月29日

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  • Hirohisa Kago,
  • Hideo Fukunaga,
  • Azusa Akiya,
  • Satoshi Akimoto,
  • Mayumi Ifuku,
  • Takeshi Iso,
  • Yu Hosono,
  • Sachie Shigemitsu,
  • Ken Takahashi,
  • Toshiaki Shimizu

摘要

In patients with manifest Wolff–Parkinson–White syndrome (WPWS), the ventricles are electrically and mechanically pre-excited via an accessory pathway (AP; left-sided AP: type A, right-sided AP: type B). Left ventricular (LV) dyssynchrony contributes to LV dysfunction. Although left atrial (LA) function is recognized as a sensitive indicator of clinical outcomes in various diseases, there have been no reports on LA function in pediatric patients with WPWS. We measured LA and LV strain and dyssynchrony indices in patients with WPWS (W-group: 36 participants) and normal controls (N-group: 41 participants) categorized by age (Group 1 ≦ 11 years, Group 2 ≧ 12 years). LA reservoir strain (LASr) in the W group was significantly lower than those in the N group in both age groups. LASr showed weak to moderate correlation with LV dyssynchrony index in Group 1 and with LV strain in Group 2. No significant differences were observed in LASr between types A and B within each age group. In Group 1, the LV longitudinal strain (LVLS) of type B was significantly lower than that in the N group. In Group 2, LVLS in both types was lower than that in the N group. The location of AP did not significantly impact LA dysfunction, which primarily correlated with LV dyssynchrony in younger patients and LV dysfunction in older patients. LA dyssynchrony was observed in both age groups. LA phasic strain may serve as an early indicator of cardiac dysfunction.