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<p>This correspondence identifies irreconcilable contradictions in Tani et al.’s article (<i>Heart Vessels</i>. 2025;40:509–522) that critically undermine its conclusions. Key concerns include paradoxical relationships between smoking and albumin–globulin ratio (AGR), discordant liver enzyme patterns, and inconsistent inflammatory marker responses. Alternative mechanisms involving humoral suppression and hepatic adaptation better explain the findings. The study’s cross-sectional design cannot resolve these discrepancies, necessitating longitudinal validation before clinical interpretation.</p>

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Association of aerobic exercise habits with higher albumin–globulin ratio and lower cellular immune-inflammatory markers: implication of the preventive effect of aerobic exercise on atherosclerotic cardiovascular disease

  • 期刊论文

  • 发表日期：

    2025年7月19日

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  • Leiying Zhang

摘要

This correspondence identifies irreconcilable contradictions in Tani et al.’s article (Heart Vessels. 2025;40:509–522) that critically undermine its conclusions. Key concerns include paradoxical relationships between smoking and albumin–globulin ratio (AGR), discordant liver enzyme patterns, and inconsistent inflammatory marker responses. Alternative mechanisms involving humoral suppression and hepatic adaptation better explain the findings. The study’s cross-sectional design cannot resolve these discrepancies, necessitating longitudinal validation before clinical interpretation.