Scholarlink

Background <p>For the design of optogenetic treatment approaches for degenerative retinal disorders two factors are of key relevance: firstly, the treatment targets a&#xa0;diseased retina where morphology and function may already be severely altered. These alterations are referred to as remodeling. The second factor is the complex signal processing in the retina, which may be altered by this remodeling or short-circuited by optogenetic therapy.</p> Research question <p>This article presents the current state of knowledge on disease-related morphological and functional remodeling processes in the retina and discusses the challenges for optogenetic treatment approaches.</p> Material and methods <p>The article presents a narrative review.</p> Results <p>Although hereditary diseases, such as retinitis pigmentosa primarily affect the outer retina, the structural and functional remodeling processes eventually affect all retinal layers. The current understanding of this process is largely based on animal studies. State-of-the-art, high-resolution imaging methods could help to gain a better understanding of remodeling in human patients and could enable identification of the optimal target cell population for optogenetic treatment approaches in patients with advanced retinal degeneration, depending on the stage of the disease.</p> Conclusion <p>Remodeling processes and retinal signal processing must be taken into account when designing optogenetic treatment approaches. In the long term the goal must be to develop targeted approaches for both ganglion cells and bipolar cells in order to make optimal use of the remaining functions depending on the stage of the disease.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Remodeling der inneren Netzhaut – Implikationen für zielgerichtete Optogenetik

  • 期刊论文

  • 发表日期：

    2026年3月6日

查看全文
  • Feros Bator,
  • Shreshth Shekhar,
  • Hans Hoerauf,
  • Tim Gollisch,
  • Christian van Oterendorp,
  • Moritz Lindner

摘要

Background

For the design of optogenetic treatment approaches for degenerative retinal disorders two factors are of key relevance: firstly, the treatment targets a diseased retina where morphology and function may already be severely altered. These alterations are referred to as remodeling. The second factor is the complex signal processing in the retina, which may be altered by this remodeling or short-circuited by optogenetic therapy.

Research question

This article presents the current state of knowledge on disease-related morphological and functional remodeling processes in the retina and discusses the challenges for optogenetic treatment approaches.

Material and methods

The article presents a narrative review.

Results

Although hereditary diseases, such as retinitis pigmentosa primarily affect the outer retina, the structural and functional remodeling processes eventually affect all retinal layers. The current understanding of this process is largely based on animal studies. State-of-the-art, high-resolution imaging methods could help to gain a better understanding of remodeling in human patients and could enable identification of the optimal target cell population for optogenetic treatment approaches in patients with advanced retinal degeneration, depending on the stage of the disease.

Conclusion

Remodeling processes and retinal signal processing must be taken into account when designing optogenetic treatment approaches. In the long term the goal must be to develop targeted approaches for both ganglion cells and bipolar cells in order to make optimal use of the remaining functions depending on the stage of the disease.