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Background <p>Basal cell carcinoma (BCC) is rare in patients ≤ 50&#xa0;years and can be associated with tumor predisposition syndromes (TPDS). The BAP1-TPDS is particularly relevant for ophthalmologists as it is associated with other malignant nonocular tumors.</p> Objective <p>Retrospective analysis of patients ≤ 50 years with periocular BCC with respect to demographic, clinical and histological features for the identification of TPDS including BAP1 staining as a possible screening procedure for BAP1-TPDS.</p> Material and methods <p>Identification of all patients ≤ 50 years with histologically confirmed BCC surgically treated at this hospital in the period 1996–2024. Documentation of the localization and histological subtype as well as evaluation of the immunohistochemical BAP1 staining.</p> Results <p>During the observational period 38 patients ≤ 50 years with a BCC of the ocular adnexa were identified including 5 patients with multiple BCC. The average age of the patients at the time of excision was 42.7 years. The histological growth pattern was predominantly nodular (89%) and the localization of the tumors was in decreasing order the lower eyelid (53%), medial eyelid angle (26%) and upper eyelid (21%). Of the patients two had a TPDS (Gorlin-Goltz syndrome and xeroderma pigmentosum). The majority of the tumors examined showed a clear BAP1 staining reaction (89%), A proportion of positive tumor cells below 25% was present in only 4 patients.</p> Conclusion <p>In the case of patients ≤ 50 years with BCC or with other tumor entities, a TPDS should be considered. The BAP1 staining is interesting in this respect as it could represent an economically favorable screening method for a BAP1-TPDS and is possible without any substantial increase in labor costs.</p>

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Charakterisierung periokulärer Basalzellkarzinome von Patienten ≤ 50 Jahre von 1996 bis 2024

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  • 发表日期：

    2025年8月6日

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  • Jonathan Meinke,
  • Karin U. Löffler,
  • Yannick N. Liermann,
  • Frank G. Holz,
  • Martina C. Herwig-Carl

摘要

Background

Basal cell carcinoma (BCC) is rare in patients ≤ 50 years and can be associated with tumor predisposition syndromes (TPDS). The BAP1-TPDS is particularly relevant for ophthalmologists as it is associated with other malignant nonocular tumors.

Objective

Retrospective analysis of patients ≤ 50 years with periocular BCC with respect to demographic, clinical and histological features for the identification of TPDS including BAP1 staining as a possible screening procedure for BAP1-TPDS.

Material and methods

Identification of all patients ≤ 50 years with histologically confirmed BCC surgically treated at this hospital in the period 1996–2024. Documentation of the localization and histological subtype as well as evaluation of the immunohistochemical BAP1 staining.

Results

During the observational period 38 patients ≤ 50 years with a BCC of the ocular adnexa were identified including 5 patients with multiple BCC. The average age of the patients at the time of excision was 42.7 years. The histological growth pattern was predominantly nodular (89%) and the localization of the tumors was in decreasing order the lower eyelid (53%), medial eyelid angle (26%) and upper eyelid (21%). Of the patients two had a TPDS (Gorlin-Goltz syndrome and xeroderma pigmentosum). The majority of the tumors examined showed a clear BAP1 staining reaction (89%), A proportion of positive tumor cells below 25% was present in only 4 patients.

Conclusion

In the case of patients ≤ 50 years with BCC or with other tumor entities, a TPDS should be considered. The BAP1 staining is interesting in this respect as it could represent an economically favorable screening method for a BAP1-TPDS and is possible without any substantial increase in labor costs.