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Outcomes after robot-assisted radical cystectomy with orthotopic neobladder in women

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2024年11月2日

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  • Juhana Rautiola,
  • Alberto Martini,
  • Laura S Mertens,
  • Viktor Skokic,
  • Luca Di Gianfrancesco,
  • Carlo Andrea Bravi,
  • Julia Heinzelbecker,
  • Mikolaj Mendrek,
  • Stephan Buse,
  • Guillaume Ploussard,
  • Hubert John,
  • Abdullah Erdem Canda,
  • Mevlana Derya Balbay,
  • Sebastian Edeling,
  • Charles Van Praet,
  • Sami-Ramzi Leyh-Bannurah,
  • Alexander Mottrie,
  • Frederiek D’Hondt,
  • Hendrik van der Poel,
  • Camille Berquin,
  • Karel Dacaestecker,
  • Richard Gaston,
  • Peter Wiklund,
  • Abolfazl Hosseini

摘要

Purpose

To investigate functional, oncological and complication outcomes in women undergoing robot-assisted cystectomy (RARC) with intracorporeal orthotopic neobladder.

Methods

From a multi-institutional database, we identified females with bladder cancer treated with RARC and intracorporeal orthotopic neobladder. We evaluated the continence rate, short-term oncological outcomes, and complication rates. Analyses were repeated and stratified by the status of preserving gynecological organs.

Results

The study involved 146 patients with the median age 60 years (IQR, 51–66 years). Pelvic organ-preserving procedure (POP) was performed in 77 patients (53%). Overall daytime and nighttime continence rates were 54% and 53%, respectively. For POP, the continence rate was 58% for both daytime and nighttime continence. In the non-POP cohort, the continence rate was 50% for daytime and 49% for nighttime continence. Both groups had balanced positive surgical margin rates (5,3% for POP and 4,7% for non-POP). In the whole cohort, high-grade (Clavien-Dindo ≥3) early and late complication rate was 7,5% and 7,5%, respectively.

Conclusions

Robot-assisted radical cystectomy with intracorporeal orthotopic neobladder in females demonstrate excellent functional and complication outcomes. Pelvic organ-preserving cystectomy enhances urinary continence rates without adversely affecting surgical margins. Orthotopic neobladder in selected women with bladder cancer, along with pelvic organ-preserving cystectomy may be used for improved functional outcomes without compromising oncological results.