Prognostic factors of intravesical recurrence after radical nephroureterectomy for upper tract urothelial carcinoma

期刊论文
发表日期：

2024年1月10日

查看全文

Chen-Ya Chen,
Chao-Hsiang Chang,
Chi-Rei Yang,
Kun-Lin Hsieh,
Wen-Hsin Tsing,
I-Hsuan Alan Chen,
Jen-Tai Lin,
Chao-Yuan Huang,
Jian-Hua Hong,
Jen-Shu Tseng,
Wun-Rong Lin,
Yao-Chou Tsai,
Shu-Yu Wu,
Cheng-Huang Shen,
Ian-Seng Cheong,
Chuan-Shu Chen,
Cheng-Kuang Yang,
Yuan-Hong Jiang,
Chung-You Tsai,
Thomas Y. Hsueh,
Yung-Tai Chen,
Chia-Chang Wu,
Shih-Hsiu Lo,
Bing-Juin Chiang,
Wei Yu Lin,
Po-Hung Lin,
Ta-Yao Tai,
Wei-Ming Li,
Hsiang-Ying Lee

摘要

Purpose

To evaluate predictive factors of increasing intravesical recurrence (IVR) rate in patients with upper tract urothelial carcinoma (UTUC) after receiving radical nephroureterectomy (RNUx) with bladder cuff excision (BCE).

Materials and methods

A total of 2114 patients were included from the updated data of the Taiwan UTUC Collaboration Group. It was divided into two groups: IVR-free and IVR after RNUx, with 1527 and 587 patients, respectively. To determine the factors affecting IVR, TNM stage, the usage of pre-operative ureteroscopy, and pathological outcomes were evaluated. The Kaplan–Meier estimator was used to estimate the rates of prognostic outcomes in overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and bladder recurrence-free survival (BRFS), and the survival curves were compared using the stratified log-rank test.

Results

Based on our research, ureter tumor, female, smoking history, age (< 70 years old), multifocal tumor, history of bladder cancer were determined to increase the risk of IVR after univariate analysis. The multivariable analysis revealed that female (BRFS for male: HR 0.566, 95% CI 0.469–0.681, p < 0.001), ureter tumor (BRFS: HR 1.359, 95% CI 1.133–1.631, p = 0.001), multifocal (BRFS: HR 1.200, 95% CI 1.001–1.439, p = 0.049), history of bladder cancer (BRFS: HR 1.480, 95% CI 1.118–1.959, p = 0.006) were the prognostic factors for IVR. Patients who ever received ureterorenoscopy (URS) did not increase the risk of IVR.

Conclusion

Patients with ureter tumor and previous bladder UC history are important factors to increase the risk of IVR after RNUx. Pre-operative URS manipulation is not associated with higher risk of IVR and diagnostic URS is feasible especially for insufficient information of image study. More frequent surveillance regimen may be needed for these patients.