<p>Micronutrient deficiencies, particularly involving iron, zinc, and provitamin A, represent a pressing global health concern. Biofortification emerges as a sustainable approach to enhance the nutritional profile of staple crops through genetic advancements, molecular breeding, and agronomic practices. Solanaceae crops, such as potatoes and tomatoes, offer a promising avenue for biofortification due to their widespread consumption, high adaptability, and genetic versatility. This review delves into recent progress in biofortification methodologies, emphasizing genetic engineering, CRISPR/Cas genome editing, QTL mapping, and transgenic technologies to improve micronutrient content in Solanaceae crops. Furthermore, it evaluates the contributions of soil and foliar fertilization, microbial-mediated biofortification, and nanoparticle-driven nutrient delivery systems. Challenges related to commercialization and societal acceptance of biofortified Solanaceae crops are also discussed. By harmonizing modern breeding techniques with cutting-edge biofortification strategies, solanaceae crops hold significant potential to advance global nutrition security.</p>