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<p>This study presents a multifunctional Au@Pt-TiO<sub>2</sub>-nano-GO nanocomposite, synthesized via a one-pot solvothermal process, as an advanced platform for cancer therapy. Under ultrasound (1&#xa0;MHz, 1&#xa0;W•cm⁻²) mimicking clinical sonodynamic therapy (SDT) conditions, it achieves ~ 95% methylene blue degradation in 25&#xa0;min, driven by nano-GO’s charge separation enhancing ROS generation (e.g., •OH). Sono-thermal effects reach 51.5&#xa0;°C at 3&#xa0;MHz, 2&#xa0;W•cm⁻², surpassing Au@Pt-TiO<sub>2</sub> (46.4&#xa0;°C) and TiO<sub>2</sub> (44.1&#xa0;°C), bridging hyperthermia and ablation for deep-tissue impact. The nanocomposite exhibits triple-enzyme mimicry—peroxidase (oxidizing OPD with H<sub>2</sub>O<sub>2</sub>), glucose oxidase (depleting glucose to gluconic acid), and catalase (decomposing H<sub>2</sub>O<sub>2</sub> to O<sub>2</sub>)—outperforming Au@Pt-TiO<sub>2</sub>, with nano-GO amplifying efficiency. These properties synergistically address tumor hypoxia (O<sub>2</sub> production), glucose supply (starvation), and ROS-mediated damage, enhanced by thermal effects. PEGylation and its ~ 20&#xa0;nm size ensure biocompatibility and cellular uptake for future translation. Unlike light-limited photothermal therapy, this ultrasound-driven approach leverages deeper penetration, offering advantages over existing TiO<sub>2</sub>-based platforms. This work underscores Au@Pt-TiO<sub>2</sub>-nano-GO’s potential as a synergistic SDT, sono-thermal, and enzyme-mimetic cancer therapy platform, warranting in vivo validation to confirm efficacy and safety.</p>

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Structural, microstructural and optical properties of Au@Pt-TiO2-nano-GO as multifunctional platform for nanomedicine applications

  • 期刊论文

  • 发表日期：

    2026年7月21日

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  • Sami Ameur,
  • Ridha Ajjel,
  • Habib Sammouda,
  • Yazeed M. Asiri,
  • Tariq Altalhi,
  • Amine Mezni

摘要

This study presents a multifunctional Au@Pt-TiO2-nano-GO nanocomposite, synthesized via a one-pot solvothermal process, as an advanced platform for cancer therapy. Under ultrasound (1 MHz, 1 W•cm⁻²) mimicking clinical sonodynamic therapy (SDT) conditions, it achieves ~ 95% methylene blue degradation in 25 min, driven by nano-GO’s charge separation enhancing ROS generation (e.g., •OH). Sono-thermal effects reach 51.5 °C at 3 MHz, 2 W•cm⁻², surpassing Au@Pt-TiO2 (46.4 °C) and TiO2 (44.1 °C), bridging hyperthermia and ablation for deep-tissue impact. The nanocomposite exhibits triple-enzyme mimicry—peroxidase (oxidizing OPD with H2O2), glucose oxidase (depleting glucose to gluconic acid), and catalase (decomposing H2O2 to O2)—outperforming Au@Pt-TiO2, with nano-GO amplifying efficiency. These properties synergistically address tumor hypoxia (O2 production), glucose supply (starvation), and ROS-mediated damage, enhanced by thermal effects. PEGylation and its ~ 20 nm size ensure biocompatibility and cellular uptake for future translation. Unlike light-limited photothermal therapy, this ultrasound-driven approach leverages deeper penetration, offering advantages over existing TiO2-based platforms. This work underscores Au@Pt-TiO2-nano-GO’s potential as a synergistic SDT, sono-thermal, and enzyme-mimetic cancer therapy platform, warranting in vivo validation to confirm efficacy and safety.