<p>In this study, magnesium ferrite (MgFe<sub>2</sub>O<sub>4</sub>) nanoparticles were successfully synthesized via an eco-friendly green route using <i>Mangifera indica</i> leaf extract (MILE) as a natural reducing and stabilizing agent. The synthesis avoided the use of hazardous chemicals, enhancing both environmental and biological compatibility. The structural properties were examined through Rietveld refinement of X-ray diffraction (XRD) data, indicating a single-phase cubic spinel structure with high crystallinity and an average crystallite size of 19&#xa0;nm. Transmission Electron Microscopy (TEM) revealed a predominantly spherical morphology with an average size of 83 ± 7&#xa0;nm, and exhibit small agglomeration. Fourier Transform Infrared Spectroscopy (FTIR) confirmed the presence of metal–oxygen bonds and phytochemical signatures from the extract. UV-Visible absorption studies demonstrated high optical absorption with a direct optical band gap energy of 2.29&#xa0;eV. Magnetic measurements using a Vibrating Sample Magnetometer (VSM) showed superparamagnetic behavior with a saturation magnetization of 40.12 emu/g and coercivity of 180 Oe, indicating potential for biomedical applications. In cytotoxicity studies, the nanoparticles exhibited dose-dependent inhibition of MDA-MB-231 breast cancer cells, achieving 20% cell viability at 200&#xa0;µg/mL concentration. These results revealed that MILE@MgFe<sub>2</sub>O<sub>4</sub> nanoparticles have modified structural, optical, magnetic, and biological properties which make them suitable for catalysis, diagnosis and therapy of cancer.</p>

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Mangifera indica-mediated MgFe2O4 nanoparticles: Structural, optical, magnetic, and cytotoxic insights

  • Anjana Sharma,
  • Jarnail Singh

摘要

In this study, magnesium ferrite (MgFe2O4) nanoparticles were successfully synthesized via an eco-friendly green route using Mangifera indica leaf extract (MILE) as a natural reducing and stabilizing agent. The synthesis avoided the use of hazardous chemicals, enhancing both environmental and biological compatibility. The structural properties were examined through Rietveld refinement of X-ray diffraction (XRD) data, indicating a single-phase cubic spinel structure with high crystallinity and an average crystallite size of 19 nm. Transmission Electron Microscopy (TEM) revealed a predominantly spherical morphology with an average size of 83 ± 7 nm, and exhibit small agglomeration. Fourier Transform Infrared Spectroscopy (FTIR) confirmed the presence of metal–oxygen bonds and phytochemical signatures from the extract. UV-Visible absorption studies demonstrated high optical absorption with a direct optical band gap energy of 2.29 eV. Magnetic measurements using a Vibrating Sample Magnetometer (VSM) showed superparamagnetic behavior with a saturation magnetization of 40.12 emu/g and coercivity of 180 Oe, indicating potential for biomedical applications. In cytotoxicity studies, the nanoparticles exhibited dose-dependent inhibition of MDA-MB-231 breast cancer cells, achieving 20% cell viability at 200 µg/mL concentration. These results revealed that MILE@MgFe2O4 nanoparticles have modified structural, optical, magnetic, and biological properties which make them suitable for catalysis, diagnosis and therapy of cancer.