Prolonged release of metformin using Met@SiO₂/PVA composite nanofibers for controlling type II diabetes

This study included the synthesis of the new nanofibers of the Met.@SiO₂/PVA (MSP) using three different amounts of metformin (0.025, 0.05, and 0.1 g) and investigates the release of the metformin in three acidic, alkaline, and neutral media. The characterization of these MSP samples was carried out using FT-IR and FESEM methods and the metformin release was monitored by UV–vis in the presence of three different amounts of 0.025, 0.05, and 0.1 g of the Met.@SiO₂/PVA gels (MSP) in the three acidities of pH (5, 7, and 9). The new findings demonstrated that the metformin release was less gradual at pH 7 than it was at pH 5 and pH 9. The results showed about 10% of the sample with 0.025 g metformin loaded on NF/Silica at pH 7 was released in the first hour, while nearly 12% and 40% metformin were released for the samples of 0.05 g and 0.1 g. During 250 h, the release of metformin was investigated at the different acidity. The advantages of using MSP nanofiber were the long time of the metformin release and the high yield of the metformin release at the acidic and alkaline media. At pH 5, the release kinetics of MSP nanofiber was in agreement with the Korsmeyer–Peppas mode and the diffusion was the primary kinetic controlling drug release. At pH 9, however, the kinetics of MSP nanofiber was following the Higuchi model. These newly fabricated nanofibers exhibited excellent and significant potential for the treatment of type 2 diabetes.