C-grooved dual-core PCF SPR biosensor with graphene/au coating for enhanced early cancer cell detection

We propose a dual-core, highly sensitive PCF SPR biosensor with C-shaped grooves based on a fusion of graphene and gold film. The performance of our sensor is enhanced by our circular fibre lattice with perforated air holes. We evaluate the biosensor's sensitivity to variations in refractive index (RI) in cancer cells numerically using the Finite Element Method (FEM) in COMSOL Multiphysics. After enhancing fiber parameters and using numerical results from amplitude method and spectral interrogation methods, we found that the biosensor demonstrates the highest sensitivity for MCF7 cells, 2142.86 nm/RIU under spectral interrogation. With HeLa cells, the biosensor shows a sensitivity of – 1058.039 1/RIU under the amplitude interrogation approach. Moreover, for MCF7, the biosensor reaches a resolution of 04.60 × 1E–5 RIU.