Scholarlink

Objectives <p>To assess the safety and diagnostic performance of CT-guided core needle biopsy (CNB) of focal pulmonary lesions with coexisting interstitial lung abnormalities (ILAs).</p> Materials and methods <p>This retrospective 1:1 matched case–control study included patients with ILAs and controls who underwent CT-guided CNB of a focal pulmonary lesion from February 2010 to December 2023. Complications, nondiagnostic specimens, and CNB diagnostic performance for malignancy were compared. Logistic regression was used to identify predictors of complications and nondiagnostic specimens. Resected cases were reviewed for histopathological changes in the nonneoplastic lung.</p> Results <p>Seventy-three patients with ILAs and matched controls were included (both groups: median age, 73.0 years; 13 women). No significant difference was found in complications (overall: 21/73 [29%] vs 24/73 [33%], <i>p</i> = 0.72; major: 2/73 [3%] vs 3/73 [4%], <i>p</i> = 1.00; minor: 19/73 [26%] vs 21/73 [29%], <i>p</i> = 0.85), nondiagnostic specimens (12/73 [16%] vs 9/73 [12%], <i>p</i> = 0.20), or diagnostic performance (accuracy: 89% [65/73] vs 96% [70/73], <i>p</i> = 0.11; sensitivity: 88% [61/69] vs 95% [62/65], <i>p</i> = 0.13; specificity: 100% [4/4] vs 100% [8/8], <i>p</i> = 1.00). Needle traversal of ILAs (OR, 7.04; 95% CI: 2.07–26.28; <i>p</i> = 0.008) and multiple pleural passes (OR, 8.06; 95% CI: 1.26–70.46; <i>p</i> = 0.03) were associated with complications. Nonneoplastic lung in ILAs revealed more complex histology and increased fibrotic features than controls.</p> Conclusion <p>CT-guided CNB of focal pulmonary lesions with coexisting ILAs was as safe and accurate as in patients without ILAs. However, traversing ILAs and multiple pleural passes increased complication risk.</p> Key Points <p><Emphasis Type="BoldItalic">Question</Emphasis> <i>Whether CT-guided CNB of focal pulmonary lesions with coexisting ILAs is as safe and accurate as in those without ILAs</i>.</p> <p><Emphasis Type="BoldItalic">Findings</Emphasis> <i>CNB in patients with ILAs showed similar safety and diagnostic performance to controls; however, complications were more frequent when ILAs were traversed or multiple pleural passes were performed</i>.</p> <p><Emphasis Type="BoldItalic">Clinical relevance</Emphasis> <i>CNB is a safe and effective diagnostic tool in patients with ILAs. Avoiding ILA traversal and multiple pleural passes may help minimize the risk of complications</i>.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

CT-guided core needle biopsy of focal pulmonary lesions with coexisting interstitial lung abnormalities: a case-control study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月30日

查看全文
  • Maurizio Balbi,
  • Luisella Righi,
  • Noemi Cristina Culasso,
  • Serena Capelli,
  • Anna Caroli,
  • Giorgia Andrea Impalà,
  • Paola Berchialla,
  • Ludwig Federico Garello,
  • Rouslan Senkeev,
  • Davide Morbidelli,
  • Giulia Reboli,
  • Stefano Levra,
  • Francesco Passiglia,
  • Nicola Sverzellati,
  • Andrea Veltri

摘要

Objectives

To assess the safety and diagnostic performance of CT-guided core needle biopsy (CNB) of focal pulmonary lesions with coexisting interstitial lung abnormalities (ILAs).

Materials and methods

This retrospective 1:1 matched case–control study included patients with ILAs and controls who underwent CT-guided CNB of a focal pulmonary lesion from February 2010 to December 2023. Complications, nondiagnostic specimens, and CNB diagnostic performance for malignancy were compared. Logistic regression was used to identify predictors of complications and nondiagnostic specimens. Resected cases were reviewed for histopathological changes in the nonneoplastic lung.

Results

Seventy-three patients with ILAs and matched controls were included (both groups: median age, 73.0 years; 13 women). No significant difference was found in complications (overall: 21/73 [29%] vs 24/73 [33%], p = 0.72; major: 2/73 [3%] vs 3/73 [4%], p = 1.00; minor: 19/73 [26%] vs 21/73 [29%], p = 0.85), nondiagnostic specimens (12/73 [16%] vs 9/73 [12%], p = 0.20), or diagnostic performance (accuracy: 89% [65/73] vs 96% [70/73], p = 0.11; sensitivity: 88% [61/69] vs 95% [62/65], p = 0.13; specificity: 100% [4/4] vs 100% [8/8], p = 1.00). Needle traversal of ILAs (OR, 7.04; 95% CI: 2.07–26.28; p = 0.008) and multiple pleural passes (OR, 8.06; 95% CI: 1.26–70.46; p = 0.03) were associated with complications. Nonneoplastic lung in ILAs revealed more complex histology and increased fibrotic features than controls.

Conclusion

CT-guided CNB of focal pulmonary lesions with coexisting ILAs was as safe and accurate as in patients without ILAs. However, traversing ILAs and multiple pleural passes increased complication risk.

Key Points

Question Whether CT-guided CNB of focal pulmonary lesions with coexisting ILAs is as safe and accurate as in those without ILAs.

Findings CNB in patients with ILAs showed similar safety and diagnostic performance to controls; however, complications were more frequent when ILAs were traversed or multiple pleural passes were performed.

Clinical relevance CNB is a safe and effective diagnostic tool in patients with ILAs. Avoiding ILA traversal and multiple pleural passes may help minimize the risk of complications.

Graphical Abstract