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Objectives <p>To develop and validate a multimodal deep learning model integrating clinical data, contrast-enhanced CT, and laryngoscopic images for differentiating early-stage (I–II) from advanced-stage (III–IV) laryngeal squamous cell carcinoma (LSCC).</p> Materials and methods <p>This retrospective multicenter study included 450 patients with pathologically confirmed LSCC from two Chinese medical centers. All patients had contrast-enhanced CT, white-light laryngoscopy, and clinical records. They were divided into training (<i>n</i> = 235), internal validation (<i>n</i> = 101), and external validation (<i>n</i> = 114) cohorts. Three single-modality models (CT-based deep learning [CT-DL], laryngoscopy-based multiple instance learning [L-MIL], and a clinical logistic regression model [CL]) and their combinations were compared. A feature-level fusion strategy was applied, and the final integrated multimodal model (CL + CT + L) was built using a stochastic gradient descent (SGD) classifier. Performance was evaluated by AUC, accuracy, sensitivity, specificity, calibration, and decision curve analysis (DCA), with prognostic value assessed by Kaplan–Meier and concordance index (<i>C</i>-index).</p> Results <p>A total of 450 patients were included (median age, 62 years [range, 31–88]; 365 men). The integrated multimodal model achieved AUCs of 0.902 (0.833–0.954) in the internal cohort and 0.888 (0.826–0.944) in the external cohort, outperforming all single- and dual-modality models (<i>p</i> &lt; 0.05). Calibration and DCA confirmed strong consistency and clinical utility. The model categorized patients into distinct risk groups, which exhibited notable differences in progression-free survival (<i>C</i>-index = 0.584, <i>p</i> = 0.036).</p> Conclusion <p>The integrated multimodal model showed high accuracy and generalizability for preoperative LSCC staging and may aid individualized treatment planning.</p> Key Points <p><Emphasis Type="BoldItalic">Question</Emphasis> <i>Can a multimodal deep learning model combining clinical, CT, and laryngoscopic data improve preoperative staging accuracy of LSCC?</i></p> <p><Emphasis Type="BoldItalic">Findings</Emphasis> <i>The integrated multimodal model achieved higher diagnostic accuracy and provided reliable prognostic stratification compared with conventional approaches</i>.</p> <p><Emphasis Type="BoldItalic">Clinical relevance</Emphasis> <i>This multimodal model offers a non-invasive, accurate, and generalizable tool for LSCC staging, supporting individualized treatment planning and enhancing patient management</i>.</p> Graphical Abstract <p></p>

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Multimodal deep learning for laryngeal squamous cell carcinoma staging using CT and laryngoscopy

  • 期刊论文

  • 发表日期：

    2026年1月30日

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  • Rui Liu,
  • Yuan Zhou,
  • Rui Wang,
  • Xinwei Chen,
  • Yi Yang,
  • Huan Jiang,
  • Kai Xie,
  • Youquan Ning,
  • Yanrui Deng,
  • Qiang Yu,
  • Lin Xu,
  • Guohua Hu,
  • Juan Peng

摘要

Objectives

To develop and validate a multimodal deep learning model integrating clinical data, contrast-enhanced CT, and laryngoscopic images for differentiating early-stage (I–II) from advanced-stage (III–IV) laryngeal squamous cell carcinoma (LSCC).

Materials and methods

This retrospective multicenter study included 450 patients with pathologically confirmed LSCC from two Chinese medical centers. All patients had contrast-enhanced CT, white-light laryngoscopy, and clinical records. They were divided into training (n = 235), internal validation (n = 101), and external validation (n = 114) cohorts. Three single-modality models (CT-based deep learning [CT-DL], laryngoscopy-based multiple instance learning [L-MIL], and a clinical logistic regression model [CL]) and their combinations were compared. A feature-level fusion strategy was applied, and the final integrated multimodal model (CL + CT + L) was built using a stochastic gradient descent (SGD) classifier. Performance was evaluated by AUC, accuracy, sensitivity, specificity, calibration, and decision curve analysis (DCA), with prognostic value assessed by Kaplan–Meier and concordance index (C-index).

Results

A total of 450 patients were included (median age, 62 years [range, 31–88]; 365 men). The integrated multimodal model achieved AUCs of 0.902 (0.833–0.954) in the internal cohort and 0.888 (0.826–0.944) in the external cohort, outperforming all single- and dual-modality models (p < 0.05). Calibration and DCA confirmed strong consistency and clinical utility. The model categorized patients into distinct risk groups, which exhibited notable differences in progression-free survival (C-index = 0.584, p = 0.036).

Conclusion

The integrated multimodal model showed high accuracy and generalizability for preoperative LSCC staging and may aid individualized treatment planning.

Key Points

Question Can a multimodal deep learning model combining clinical, CT, and laryngoscopic data improve preoperative staging accuracy of LSCC?

Findings The integrated multimodal model achieved higher diagnostic accuracy and provided reliable prognostic stratification compared with conventional approaches.

Clinical relevance This multimodal model offers a non-invasive, accurate, and generalizable tool for LSCC staging, supporting individualized treatment planning and enhancing patient management.

Graphical Abstract