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Objectives <p>This study evaluated serial magnetic resonance fingerprinting (MRF)-derived T<sub>1</sub> and T<sub>2</sub> relaxivities of prostate bone metastasis compared with conventional T<sub>1</sub> and T<sub>2</sub> measurements.</p> Materials and methods <p>This prospective study (July 2020 to July 2022) included MRF and conventional MRI acquisitions (T<sub>1</sub>: inversion-recovery turbo spin echo; T<sub>2</sub>: dual spin echo) from participants with bone metastasis from primary prostate cancer from two cohorts: pre-treatment (<i>N</i> = 34) and pre/post-treatment (<i>N</i> = 19). Phantom/human data were acquired on a 1.5-T scanner using an MRF sequence outputting T<sub>1</sub> and T<sub>2</sub> maps. Regions of interest (ROIs) of bone metastasis were drawn per visit on both MRF and conventional MRI. Inter-method reproducibility of T<sub>1</sub> and T<sub>2</sub> was assessed using Bland–Altman plots, reproducibility, intraclass correlation, and Spearman correlation coefficients. A delta parameter [post-treatment – pre-treatment] of method-specific T<sub>1</sub> and T<sub>2</sub> was reported.</p> Results <p>Thirty-four patients with metastatic prostate cancer (mean age, 68 years ± 7 [standard deviation]) were evaluated pre-treatment; 19 participants were further scanned post-treatment. MRF-derived mean T<sub>1</sub> and T<sub>2</sub> in bone metastasis were slightly higher than the conventional MR measurements: 10.8% (T<sub>1</sub>) and 15.5% (T<sub>2</sub>). The reproducibility coefficient (r%) was 19.3% for T<sub>1</sub> and 32.5% for T<sub>2</sub>, whilst the Spearman correlation coefficient was strong for both parameters (0.66, <i>p</i> &lt; 0.001 and 0.70, <i>p</i> &lt; 0.001). The MRF-derived delta T<sub>1</sub> parameter was moderately correlated to the inversion-recovery method (0.59, <i>p</i> = 0.008), whilst the MRF-derived delta T<sub>2</sub> was very strongly correlated to the dual spin echo method (0.80, <i>p</i> &lt; 0.001).</p> Conclusion <p>A good correlation of MRF-derived T<sub>1</sub> and T<sub>2</sub> measurements with conventional quantitative methods was demonstrated in bone metastasis.</p> Key Points <p><Emphasis Type="BoldItalic">Question</Emphasis> <i>MR fingerprinting (MRF)-derived T</i><sub><i>1</i></sub> <i>and T</i><sub><i>2</i></sub> <i>values have the potential to characterise bone metastasis and treatment response, but their performance against conventional MRI is unclear</i>.</p> <p><Emphasis Type="BoldItalic">Findings</Emphasis> <i>The inter-method reproducibility coefficient was 19.3% for T</i><sub><i>1</i></sub> <i>and 32.5% for T</i><sub><i>2</i></sub>, <i>whilst the Spearman correlation coefficient was strong for both parameters</i>.</p> <p><Emphasis Type="BoldItalic">Clinical relevance</Emphasis> <i>Serial MRF-derived T</i><sub><i>1</i></sub> <i>and T</i><sub><i>2</i></sub> <i>measurements in bone metastasis in patients with prostate cancer correlated well with conventional MRI measurements, supporting MRF use for faster quantitative measurements in bone lesions</i>.</p> Graphical Abstract <p></p>

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Serial T1 and T2 measurements of metastatic bone lesions in prostate cancer patients: MR fingerprinting vs conventional MRI

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月24日

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  • Mihaela Rata,
  • Nina Tunariu,
  • Yun Jiang,
  • Julie Hughes,
  • Georgina Hopkinson,
  • Erica Scurr,
  • Jessica M. Winfield,
  • Vikas Gulani,
  • Dow-Mu Koh,
  • Matthew R. Orton

摘要

Objectives

This study evaluated serial magnetic resonance fingerprinting (MRF)-derived T1 and T2 relaxivities of prostate bone metastasis compared with conventional T1 and T2 measurements.

Materials and methods

This prospective study (July 2020 to July 2022) included MRF and conventional MRI acquisitions (T1: inversion-recovery turbo spin echo; T2: dual spin echo) from participants with bone metastasis from primary prostate cancer from two cohorts: pre-treatment (N = 34) and pre/post-treatment (N = 19). Phantom/human data were acquired on a 1.5-T scanner using an MRF sequence outputting T1 and T2 maps. Regions of interest (ROIs) of bone metastasis were drawn per visit on both MRF and conventional MRI. Inter-method reproducibility of T1 and T2 was assessed using Bland–Altman plots, reproducibility, intraclass correlation, and Spearman correlation coefficients. A delta parameter [post-treatment – pre-treatment] of method-specific T1 and T2 was reported.

Results

Thirty-four patients with metastatic prostate cancer (mean age, 68 years ± 7 [standard deviation]) were evaluated pre-treatment; 19 participants were further scanned post-treatment. MRF-derived mean T1 and T2 in bone metastasis were slightly higher than the conventional MR measurements: 10.8% (T1) and 15.5% (T2). The reproducibility coefficient (r%) was 19.3% for T1 and 32.5% for T2, whilst the Spearman correlation coefficient was strong for both parameters (0.66, p < 0.001 and 0.70, p < 0.001). The MRF-derived delta T1 parameter was moderately correlated to the inversion-recovery method (0.59, p = 0.008), whilst the MRF-derived delta T2 was very strongly correlated to the dual spin echo method (0.80, p < 0.001).

Conclusion

A good correlation of MRF-derived T1 and T2 measurements with conventional quantitative methods was demonstrated in bone metastasis.

Key Points

Question MR fingerprinting (MRF)-derived T1 and T2 values have the potential to characterise bone metastasis and treatment response, but their performance against conventional MRI is unclear.

Findings The inter-method reproducibility coefficient was 19.3% for T1 and 32.5% for T2, whilst the Spearman correlation coefficient was strong for both parameters.

Clinical relevance Serial MRF-derived T1 and T2 measurements in bone metastasis in patients with prostate cancer correlated well with conventional MRI measurements, supporting MRF use for faster quantitative measurements in bone lesions.

Graphical Abstract