Objectives To compare 40 keV virtual monochromatic images (VMIs) with conventionally acquired polychromatic multi-detector CT images (CONV) in patients with acute bowel ischaemia (ABI). Materials and methods We retrospectively included 48 consecutive patients (38 males, mean age 69 years) with pathologically proven ABI over 40 months. They underwent portovenous dual-energy multi-detector CT followed by surgery within < 48 h. Nineteen patients had VMIs, and 29 had CONV after non-enhanced acquisition. After dividing the small and large bowel into 10 segments, two radiologists blinded to the exact localisation of the ABI read the VMIs and CONV images separately. After this qualitative analysis, bowel wall density was assessed quantitatively on (virtual) non-enhanced and portovenous images. Results Qualitative analysis showed good overall sensitivity (75.9–82%) and specificity (85.9–88.7%) for localising ABI on VMIs and CONV images without significant differences. Inter-observer agreement was important or near perfect (kappa 0.61–0.83). Quantitative analysis revealed significant differences in wall density between healthy and pathological bowel segments for nearly all VMIs and CONV images, not only when analysing the (virtual) non-enhanced and portovenous phases separately, but also when subtracting wall density (portovenous minus (virtual) non-enhanced phase). Wall density delta (healthy minus pathological wall) showed no significant differences between VMIs and CONV images. Conclusion VMIs and CONV images had good diagnostic value and important inter-reader agreement for localising ABI using (virtual) non-enhanced and portovenous phases, without significant qualitative or quantitative differences. Therefore, we can rely on the virtual non-enhanced phase instead of additionally acquiring a non-enhanced phase, enabling considerable dose reduction. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> Can we rely on virtual monochromatic CT images to detect reduced or absent bowel wall enhancement in acute bowel ischaemia? <Emphasis Type="BoldItalic">Findings</Emphasis> Virtual monochromatic CT images have equal diagnostic value for detecting acute bowel ischaemia as conventionally acquired polychromatic CT images without significant qualitative or quantitative differences. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> Significant differences in bowel wall density between healthy and pathological segments on subtraction virtual monochromatic images allow us to rely on the virtual non-enhanced phase instead of acquiring an additional non-enhanced phase in acute bowel ischaemia, leading to dose reduction. Graphical Abstract

Virtual monochromatic versus conventional polychromatic CT images in patients with acute bowel ischaemia

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2025年9月12日

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Kilian Rothenbuehler,
Ahmad Sayadi,
Renaud Troxler,
Christine Sempoux,
Alban Denys,
David Rotzinger,
Sabine Schmidt

摘要

Objectives

To compare 40 keV virtual monochromatic images (VMIs) with conventionally acquired polychromatic multi-detector CT images (CONV) in patients with acute bowel ischaemia (ABI).

Materials and methods

We retrospectively included 48 consecutive patients (38 males, mean age 69 years) with pathologically proven ABI over 40 months. They underwent portovenous dual-energy multi-detector CT followed by surgery within < 48 h. Nineteen patients had VMIs, and 29 had CONV after non-enhanced acquisition. After dividing the small and large bowel into 10 segments, two radiologists blinded to the exact localisation of the ABI read the VMIs and CONV images separately. After this qualitative analysis, bowel wall density was assessed quantitatively on (virtual) non-enhanced and portovenous images.

Results

Qualitative analysis showed good overall sensitivity (75.9–82%) and specificity (85.9–88.7%) for localising ABI on VMIs and CONV images without significant differences. Inter-observer agreement was important or near perfect (kappa 0.61–0.83). Quantitative analysis revealed significant differences in wall density between healthy and pathological bowel segments for nearly all VMIs and CONV images, not only when analysing the (virtual) non-enhanced and portovenous phases separately, but also when subtracting wall density (portovenous minus (virtual) non-enhanced phase). Wall density delta (healthy minus pathological wall) showed no significant differences between VMIs and CONV images.

Conclusion

VMIs and CONV images had good diagnostic value and important inter-reader agreement for localising ABI using (virtual) non-enhanced and portovenous phases, without significant qualitative or quantitative differences. Therefore, we can rely on the virtual non-enhanced phase instead of additionally acquiring a non-enhanced phase, enabling considerable dose reduction.

Key Points

Question Can we rely on virtual monochromatic CT images to detect reduced or absent bowel wall enhancement in acute bowel ischaemia?

Findings Virtual monochromatic CT images have equal diagnostic value for detecting acute bowel ischaemia as conventionally acquired polychromatic CT images without significant qualitative or quantitative differences.

Clinical relevance Significant differences in bowel wall density between healthy and pathological segments on subtraction virtual monochromatic images allow us to rely on the virtual non-enhanced phase instead of acquiring an additional non-enhanced phase in acute bowel ischaemia, leading to dose reduction.

Graphical Abstract