Objectives To evaluate the predictive role of carotid stiffening, quantified using ultrafast pulse wave velocity (ufPWV), for assessing cardiovascular risk in young populations with no or elevated cardiovascular risk factors (CVRFs). Materials and methods This study enrolled 180 young, apparently healthy individuals who underwent ufPWV measurements. They were classified into three groups: the CVRF-free group (n = 60), comprising current non-smokers with untreated blood pressure < 140/90 mmHg, fasting blood glucose (FBG) < 7.0 mmol/L, total cholesterol (TC) < 6.2 mmol/L, low-density lipoprotein < 4.1 mmol/L, and high-density lipoprotein ≥ 1.0 mmol/L; the CVRF-optimal group (n = 54), including those with untreated blood pressure < 120/80 mmHg, TC < 5.2 mmol/L, and FBG < 5.6 mmol/L; and the atherosclerosis (AS)-risk group (n = 66), with participants who did not meet the aforementioned criteria. Adjusted odds ratios (ORs) with 95% confidence intervals and ordinal logistic regression models were used. Results Carotid stiffening significantly differed among CVRF groups at both participant and carotid levels, and across age, sex, and carotid intima-media thickness subgroups (all p < 0.05). Carotid stiffening significantly correlated with age (r up to 0.464, p < 0.001) and BMI (r up to 0.502, p < 0.001) overall, in CVRF groups, and in men and women. Increased carotid stiffness was associated with elevated CVRFs in young populations, with the OR of 2.21–7.71, independent of major CVRFs. Conclusion ufPWV-estimated carotid stiffening can be a promising tool for early detection of cardiovascular risk in young populations with no or elevated CVRFs. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> What is the association between cardiovascular risk, as characterized by exposure to varying levels of cardiovascular risk factors (CVRFs), and carotid stiffening in young populations? <Emphasis Type="BoldItalic">Findings</Emphasis> Ultrafast pulse wave velocity (ufPWV)-estimated carotid stiffening is associated with cardiovascular risk in young populations with optimal, normal, and elevated CVRFs, independent of major CVRFs. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> ufPWV can be a promising quantitative predictor for assessing cardiovascular risk in young people. Its potential discrimination helps improve the understanding of early atherogenesis and guides the clinical assessment of enhanced cardiovascular risk in adults under 40 years of age. Graphical Abstract

Association of cardiovascular risks and carotid stiffening at ultrafast ultrasound imaging in young populations

期刊论文
发表日期：

2025年9月8日

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Zhengqiu Zhu,
Lingshan Chen,
Wenjun Liu,
Chong Zou,
Yinping Wang,
Yiyun Wu,
Bixiao Shen,
Xuehui Ma,
Hui Gao,
Ping Dai,
Hui Huang

摘要

Objectives

To evaluate the predictive role of carotid stiffening, quantified using ultrafast pulse wave velocity (ufPWV), for assessing cardiovascular risk in young populations with no or elevated cardiovascular risk factors (CVRFs).

Materials and methods

This study enrolled 180 young, apparently healthy individuals who underwent ufPWV measurements. They were classified into three groups: the CVRF-free group (n = 60), comprising current non-smokers with untreated blood pressure < 140/90 mmHg, fasting blood glucose (FBG) < 7.0 mmol/L, total cholesterol (TC) < 6.2 mmol/L, low-density lipoprotein < 4.1 mmol/L, and high-density lipoprotein ≥ 1.0 mmol/L; the CVRF-optimal group (n = 54), including those with untreated blood pressure < 120/80 mmHg, TC < 5.2 mmol/L, and FBG < 5.6 mmol/L; and the atherosclerosis (AS)-risk group (n = 66), with participants who did not meet the aforementioned criteria. Adjusted odds ratios (ORs) with 95% confidence intervals and ordinal logistic regression models were used.

Results

Carotid stiffening significantly differed among CVRF groups at both participant and carotid levels, and across age, sex, and carotid intima-media thickness subgroups (all p < 0.05). Carotid stiffening significantly correlated with age (r up to 0.464, p < 0.001) and BMI (r up to 0.502, p < 0.001) overall, in CVRF groups, and in men and women. Increased carotid stiffness was associated with elevated CVRFs in young populations, with the OR of 2.21–7.71, independent of major CVRFs.

Conclusion

ufPWV-estimated carotid stiffening can be a promising tool for early detection of cardiovascular risk in young populations with no or elevated CVRFs.

Key Points

Question What is the association between cardiovascular risk, as characterized by exposure to varying levels of cardiovascular risk factors (CVRFs), and carotid stiffening in young populations?

Findings Ultrafast pulse wave velocity (ufPWV)-estimated carotid stiffening is associated with cardiovascular risk in young populations with optimal, normal, and elevated CVRFs, independent of major CVRFs.

Clinical relevance ufPWV can be a promising quantitative predictor for assessing cardiovascular risk in young people. Its potential discrimination helps improve the understanding of early atherogenesis and guides the clinical assessment of enhanced cardiovascular risk in adults under 40 years of age.

Graphical Abstract