Objectives Evaluation of extranodal extension (ENE) after neoadjuvant chemoradiotherapy (nCRT) might improve the currently suboptimal prognostic implication of preoperative nodal evaluation in rectal cancer, but evidence is lacking. The aim of this study was to evaluate diagnostic accuracy and prognostic value of MRI-determined ENE after nCRT in rectal cancer. Materials and methods This single-center study included a prospective developing dataset and a retrospective validation cohort, which enrolled patients who underwent nCRT and surgery from 2021 to 2023 and 2018 to 2019, respectively. In the developing dataset, participants were chronologically divided into training and test sets in 3:1 ratio and multiparametric features were analyzed on MRI before and after nCRT (hereafter, post-nCRT) in nodes that achieved per-node matching with pathology. The diagnostic process was established with logistic analyses and evaluated with areas under the receiver operating characteristic curve (AUCs). In the validation cohort, potential risk factors were evaluated, and Cox analysis was used to explore their association with disease-free survival (DFS). Results 208 participants were included in the developing dataset. The post-nCRT process, which incorporated the tail sign and vessel interruption on post-nCRT MRI, yielded AUCs of 0.86 (95% CI: 0.82, 0.89) and 0.83 (95% CI: 0.76, 0.89) in the training and test sets, respectively. In the validation cohort of 123 patients, the presence of ENE on post-nCRT MRI was demonstrated to be an independent risk factor for DFS (p = 0.02). Conclusion The evaluation of ENE after nCRT better predicts prognosis, whose presence may serve as an indicator of intensified therapy in rectal cancer patients. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> Evidence of evaluating the extranodal extension (ENE), a pathological prognostic indicator, on MRI after neoadjuvant chemoradiotherapy (nCRT) is lacking in rectal cancer. <Emphasis Type="BoldItalic">Findings</Emphasis> ENE could be detected by only two features on post-nCRT MRI, and its presence was associated with poorer disease-free survival. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> The preoperative evaluation of ENE after nCRT improved the currently suboptimal contribution of nodal evaluation to prognostication in rectal cancer patients. Graphical Abstract

Extranodal extension on MRI after neoadjuvant chemoradiotherapy improves the prognostic contribution of nodal evaluation in rectal cancer

期刊论文
发表日期：

2025年7月2日

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Qing-Yang Li,
Ding Yang,
Zhen Guan,
Xin-Yue Yan,
Xiao-Ting Li,
Rui-Jia Sun,
Qiao-Yuan Lu,
Xiao-Yan Zhang,
Ying-Shi Sun

摘要

Objectives

Evaluation of extranodal extension (ENE) after neoadjuvant chemoradiotherapy (nCRT) might improve the currently suboptimal prognostic implication of preoperative nodal evaluation in rectal cancer, but evidence is lacking. The aim of this study was to evaluate diagnostic accuracy and prognostic value of MRI-determined ENE after nCRT in rectal cancer.

Materials and methods

This single-center study included a prospective developing dataset and a retrospective validation cohort, which enrolled patients who underwent nCRT and surgery from 2021 to 2023 and 2018 to 2019, respectively. In the developing dataset, participants were chronologically divided into training and test sets in 3:1 ratio and multiparametric features were analyzed on MRI before and after nCRT (hereafter, post-nCRT) in nodes that achieved per-node matching with pathology. The diagnostic process was established with logistic analyses and evaluated with areas under the receiver operating characteristic curve (AUCs). In the validation cohort, potential risk factors were evaluated, and Cox analysis was used to explore their association with disease-free survival (DFS).

Results

208 participants were included in the developing dataset. The post-nCRT process, which incorporated the tail sign and vessel interruption on post-nCRT MRI, yielded AUCs of 0.86 (95% CI: 0.82, 0.89) and 0.83 (95% CI: 0.76, 0.89) in the training and test sets, respectively. In the validation cohort of 123 patients, the presence of ENE on post-nCRT MRI was demonstrated to be an independent risk factor for DFS (p = 0.02).

Conclusion

The evaluation of ENE after nCRT better predicts prognosis, whose presence may serve as an indicator of intensified therapy in rectal cancer patients.

Key Points

Question Evidence of evaluating the extranodal extension (ENE), a pathological prognostic indicator, on MRI after neoadjuvant chemoradiotherapy (nCRT) is lacking in rectal cancer.

Findings ENE could be detected by only two features on post-nCRT MRI, and its presence was associated with poorer disease-free survival.

Clinical relevance The preoperative evaluation of ENE after nCRT improved the currently suboptimal contribution of nodal evaluation to prognostication in rectal cancer patients.

Graphical Abstract