Objectives To evaluate the diagnostic performance of lumbar spine CT using deep learning denoising (DLD CT) for detecting disc herniation and spinal stenosis. Materials and methods This retrospective study included 47 patients (229 intervertebral discs from L1/2 to L5/S1; 18 men and 29 women; mean age, 69.1 ± 10.9 years) who underwent lumbar spine CT and MRI within 1 month. CT images were reconstructed using filtered back projection (FBP) and denoised using a deep learning algorithm (ClariCT.AI). Three radiologists independently evaluated standard CT and DLD CT at an 8-week interval for the presence of disc herniation, central canal stenosis, and neural foraminal stenosis. Subjective image quality and diagnostic confidence were also assessed using five-point Likert scales. Standard CT and DLD CT were compared using MRI as a reference standard. Results DLD CT showed higher sensitivity (60% (70/117) vs. 44% (51/117); p < 0.001) and similar specificity (94% (534/570) vs. 94% (538/570); p = 0.465) for detecting disc herniation. Specificity for detecting spinal canal stenosis and neural foraminal stenosis was higher in DLD CT (90% (487/540) vs. 86% (466/540); p = 0.003, 94% (1202/1272) vs. 92% (1171/1272); p < 0.001), while sensitivity was comparable (81% (119/147) vs. 77% (113/147); p = 0.233, 83% (85/102) vs. 81% (83/102); p = 0.636). Image quality and diagnostic confidence were superior for DLD CT (all comparisons, p < 0.05). Conclusion Compared to standard CT, DLD CT can improve diagnostic performance in detecting disc herniation and spinal stenosis with superior image quality and diagnostic confidence. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> The accurate diagnosis of disc herniation and spinal stenosis is limited on lumbar spine CT because of the low soft-tissue contrast. <Emphasis Type="BoldItalic">Findings</Emphasis> Lumbar spine CT using deep learning denoising (DLD CT) demonstrated superior diagnostic performance in detecting disc herniation and spinal stenosis compared to standard CT. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> DLD CT can be used as a simple and cost-effective screening test. Graphical Abstract

Diagnostic performance of lumbar spine CT using deep learning denoising to evaluate disc herniation and spinal stenosis

期刊论文
发表日期：

2025年6月7日

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Sungeun Park,
Ji Hee Kang,
Sung Gyu Moon

摘要

Objectives

To evaluate the diagnostic performance of lumbar spine CT using deep learning denoising (DLD CT) for detecting disc herniation and spinal stenosis.

Materials and methods

This retrospective study included 47 patients (229 intervertebral discs from L1/2 to L5/S1; 18 men and 29 women; mean age, 69.1 ± 10.9 years) who underwent lumbar spine CT and MRI within 1 month. CT images were reconstructed using filtered back projection (FBP) and denoised using a deep learning algorithm (ClariCT.AI). Three radiologists independently evaluated standard CT and DLD CT at an 8-week interval for the presence of disc herniation, central canal stenosis, and neural foraminal stenosis. Subjective image quality and diagnostic confidence were also assessed using five-point Likert scales. Standard CT and DLD CT were compared using MRI as a reference standard.

Results

DLD CT showed higher sensitivity (60% (70/117) vs. 44% (51/117); p < 0.001) and similar specificity (94% (534/570) vs. 94% (538/570); p = 0.465) for detecting disc herniation. Specificity for detecting spinal canal stenosis and neural foraminal stenosis was higher in DLD CT (90% (487/540) vs. 86% (466/540); p = 0.003, 94% (1202/1272) vs. 92% (1171/1272); p < 0.001), while sensitivity was comparable (81% (119/147) vs. 77% (113/147); p = 0.233, 83% (85/102) vs. 81% (83/102); p = 0.636). Image quality and diagnostic confidence were superior for DLD CT (all comparisons, p < 0.05).

Conclusion

Compared to standard CT, DLD CT can improve diagnostic performance in detecting disc herniation and spinal stenosis with superior image quality and diagnostic confidence.

Key Points

Question The accurate diagnosis of disc herniation and spinal stenosis is limited on lumbar spine CT because of the low soft-tissue contrast.

Findings Lumbar spine CT using deep learning denoising (DLD CT) demonstrated superior diagnostic performance in detecting disc herniation and spinal stenosis compared to standard CT.

Clinical relevance DLD CT can be used as a simple and cost-effective screening test.

Graphical Abstract