Objectives Noncontrast-abbreviated magnetic resonance imaging (NC-AMRI) is emerging as a promising alternative to ultrasound (US) for surveillance of hepatocellular carcinoma (HCC) in at-risk patients. We aimed to assess the effectiveness of NC-AMRI in a real-world surveillance population, and to evaluate the appropriateness of NC-AMRI in selected patients with inadequate prior US. Materials and methods This retrospective study included Child–Pugh class A or B adults with chronic hepatitis B or cirrhosis from any cause who underwent NC-AMRI between December 2018 and August 2022. Early- and very early-stage detection, receipt of curative treatment, and false referral were evaluated. Subgroup analysis was performed for patients with inadequate prior US examinations. Descriptive statistics were used. Results Among the 1853 patients (mean age, 58.8 years; 1045 males), 68 HCCs developed in 61 (61/1853, 3.3%, 95% confidence interval: 2.5–4.2) patients. The proportions of early- and very early-stage detection were 95.1% (58/61, 72.2–100.0) and 70.5% (43/61, 51.0–95.0); receipt of curative treatment, 67.2% (41/61, 48.2–91.2); and proportion of false referral, 12.9% (9/70, 5.9–24.4). Among the 375 patients with inadequate prior US, the proportions of early- and very early-stage detection were 94.7% (18/19, 56.2–100.0) and 57.9% (11/19, 28.9–100.0); receipt of curative treatment, 52.6% (10/19, 25.2–96.8); and proportion of false referrals, 17.4% (4/23, 4.7–44.5). Conclusion NC-AMRI may be an effective HCC surveillance modality given the results related to early- and very early-stage detection, receipt of curative treatment, and false referral. NC-AMRI can be an alternative HCC surveillance strategy, especially for patients with inadequate prior US examinations. Key Points <Emphasis Type="BoldItalic">Question</Emphasis> There is insufficient evidence to support the use of noncontrast-abbreviated MRI as an effective surveillance tool in large real-life populations under surveillance. <Emphasis Type="BoldItalic">Findings</Emphasis> Using noncontrast-abbreviated MRI, most patients who developed HCCs during surveillance were diagnosed at an early stage, with an acceptable false referral rate of 12.9%. <Emphasis Type="BoldItalic">Clinical relevance</Emphasis> Noncontrast-abbreviated MRI is an effective HCC surveillance modality, especially for patients with inadequate prior ultrasound examinations. Graphical Abstract

Effectiveness of noncontrast-abbreviated magnetic resonance imaging in a real-world hepatocellular carcinoma surveillance

期刊论文
发表日期：

2025年3月20日

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Hyun Kyung Yang,
Sunyoung Lee,
Min Young Lee,
Myeong-Jin Kim

摘要

Objectives

Noncontrast-abbreviated magnetic resonance imaging (NC-AMRI) is emerging as a promising alternative to ultrasound (US) for surveillance of hepatocellular carcinoma (HCC) in at-risk patients. We aimed to assess the effectiveness of NC-AMRI in a real-world surveillance population, and to evaluate the appropriateness of NC-AMRI in selected patients with inadequate prior US.

Materials and methods

This retrospective study included Child–Pugh class A or B adults with chronic hepatitis B or cirrhosis from any cause who underwent NC-AMRI between December 2018 and August 2022. Early- and very early-stage detection, receipt of curative treatment, and false referral were evaluated. Subgroup analysis was performed for patients with inadequate prior US examinations. Descriptive statistics were used.

Results

Among the 1853 patients (mean age, 58.8 years; 1045 males), 68 HCCs developed in 61 (61/1853, 3.3%, 95% confidence interval: 2.5–4.2) patients. The proportions of early- and very early-stage detection were 95.1% (58/61, 72.2–100.0) and 70.5% (43/61, 51.0–95.0); receipt of curative treatment, 67.2% (41/61, 48.2–91.2); and proportion of false referral, 12.9% (9/70, 5.9–24.4). Among the 375 patients with inadequate prior US, the proportions of early- and very early-stage detection were 94.7% (18/19, 56.2–100.0) and 57.9% (11/19, 28.9–100.0); receipt of curative treatment, 52.6% (10/19, 25.2–96.8); and proportion of false referrals, 17.4% (4/23, 4.7–44.5).

Conclusion

NC-AMRI may be an effective HCC surveillance modality given the results related to early- and very early-stage detection, receipt of curative treatment, and false referral. NC-AMRI can be an alternative HCC surveillance strategy, especially for patients with inadequate prior US examinations.

Key Points

Question There is insufficient evidence to support the use of noncontrast-abbreviated MRI as an effective surveillance tool in large real-life populations under surveillance.

Findings Using noncontrast-abbreviated MRI, most patients who developed HCCs during surveillance were diagnosed at an early stage, with an acceptable false referral rate of 12.9%.

Clinical relevance Noncontrast-abbreviated MRI is an effective HCC surveillance modality, especially for patients with inadequate prior ultrasound examinations.

Graphical Abstract