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Objectives <p>Tumor collagen is vital in chemotherapy resistance of pancreatic cancer (PC), but its non-invasive evaluation remains challenging. This study aims to investigate the association of variables derived from dual-energy CT with the collagen ratio (CR) of PC and to determine the prognostic value of CR in unresectable diseases.</p> Materials and methods <p>A total of 83 patients with resected PC and 71 patients with unresectable PC were enrolled. In the resected group, the correlation between the tumor CR and variables of dual-energy CT was analyzed. In the unresectable group, Cox regression analyses were conducted to investigate the prognostic value of dual-energy CT-predicted CR and other clinicoradiological indicators.</p> Results <p>The patients with resected PC were divided into low and high-CR sets with a threshold of 55%. In the resected group, the extracellular volume fraction calculated by the iodine concentration (ECV_IC) was the only predictor of tumor CR according to univariate and multivariate analysis (odds ratio [OR] (95% confidence interval [CI]):1.19 [1.03–1.37]). The correlation coefficient <i>r</i> was 0.26 (<i>p</i> = 0.02) between ECV_IC and specific CR values. In the training set of unresectable PC group, ECV_IC (hazard ratio [HR] (95% CI): 0.94 (0.89–0.99), <i>p</i> = 0.03) and contrast-enhanced pattern (CEP) (HR (95% CI): 3.20 (1.41–7.27), <i>p</i> = 0.01) were independent prognostic factors for overall survival. The nomogram model was constructed and showed a good performance.</p> Conclusion <p>The ECV_IC is a non-invasive indicator of tumor CR in PC. The ECV_IC and CEP have the potential to predict the prognosis of unresectable PC.</p> Key Points <p><Emphasis Type="BoldItalic">Question</Emphasis> <i>Non-invasive evaluation of tumor collagen, a vital determinant of chemotherapy resistance of pancreatic cancer, remains challenging.</i></p> <p><Emphasis Type="BoldItalic">Findings</Emphasis> <i>Tumor collagen ratio can be noninvasively predicted by extracellular volume fraction based on iodine concentration.</i></p> <p><Emphasis Type="BoldItalic">Clinical relevance</Emphasis> <i>The nomogram model composed of extracellular volume fraction and contrast-enhanced pattern can serve as an effective and convenient tool for stratifying the prognosis of patients with unresectable pancreatic cancer.</i></p> Graphical Abstract <p></p>

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Dual-energy CT extracellular volume fraction predicts tumor collagen ratio and possibly survival for inoperable pancreatic cancer patients

  • 期刊论文

  • 发表日期：

    2025年2月8日

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  • Wei Liu,
  • Yi Chen,
  • Tiansong Xie,
  • Zehua Zhang,
  • Yu Wang,
  • Xuebin Xie,
  • Lei Chen,
  • Zhengrong Zhou

摘要

Objectives

Tumor collagen is vital in chemotherapy resistance of pancreatic cancer (PC), but its non-invasive evaluation remains challenging. This study aims to investigate the association of variables derived from dual-energy CT with the collagen ratio (CR) of PC and to determine the prognostic value of CR in unresectable diseases.

Materials and methods

A total of 83 patients with resected PC and 71 patients with unresectable PC were enrolled. In the resected group, the correlation between the tumor CR and variables of dual-energy CT was analyzed. In the unresectable group, Cox regression analyses were conducted to investigate the prognostic value of dual-energy CT-predicted CR and other clinicoradiological indicators.

Results

The patients with resected PC were divided into low and high-CR sets with a threshold of 55%. In the resected group, the extracellular volume fraction calculated by the iodine concentration (ECV_IC) was the only predictor of tumor CR according to univariate and multivariate analysis (odds ratio [OR] (95% confidence interval [CI]):1.19 [1.03–1.37]). The correlation coefficient r was 0.26 (p = 0.02) between ECV_IC and specific CR values. In the training set of unresectable PC group, ECV_IC (hazard ratio [HR] (95% CI): 0.94 (0.89–0.99), p = 0.03) and contrast-enhanced pattern (CEP) (HR (95% CI): 3.20 (1.41–7.27), p = 0.01) were independent prognostic factors for overall survival. The nomogram model was constructed and showed a good performance.

Conclusion

The ECV_IC is a non-invasive indicator of tumor CR in PC. The ECV_IC and CEP have the potential to predict the prognosis of unresectable PC.

Key Points

Question Non-invasive evaluation of tumor collagen, a vital determinant of chemotherapy resistance of pancreatic cancer, remains challenging.

Findings Tumor collagen ratio can be noninvasively predicted by extracellular volume fraction based on iodine concentration.

Clinical relevance The nomogram model composed of extracellular volume fraction and contrast-enhanced pattern can serve as an effective and convenient tool for stratifying the prognosis of patients with unresectable pancreatic cancer.

Graphical Abstract