Evaluation of pancreatic iodine uptake and related influential factors in multiphase dual-energy CT

期刊论文
发表日期：

2024年6月24日

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Chen Pan,
Tao Yu,
Heng Zhao,
Jiani He,
Xiaomei Lu,
Haiyan Tang,
Yang Hong,
Chao Shang,
Qijun Wu,
Aoran Yang,
Chunli Li,
Minghui Zhou,
Yu Shi

摘要

Objectives

To establish normative values and identify potential factors influencing pancreatic iodine uptake using dual-energy CT (DECT).

Materials and methods

This retrospective study included participants without pancreatic diseases undergoing DECT at two institutions with different platforms. Their protocols both included arterial phase (AP), portal venous phase (PP), and equilibrium phase (EP), defined as 35 s–40 s, 60 s–70 s, and 150 s–180 s after injection of contrast agent, respectively. Both iodine concentration (IC) and normalised IC (NIC) were measured. Demographic features, local measurements of the pancreas and visceral fat area (VFA) were considered as potential factors influencing iodine uptake using multivariate linear regression analyses.

Results

A total of 562 participants (median age 58 years [interquartile range: 47–67], with 282 men) were evaluated. The mean IC differed significantly between two institutions (all p < 0.001) across three contrast-enhanced phases, while the mean NIC showed no significant differences (all p > 0.05). The mean values of NIC were 0.22 at AP, 0.43 at PP and 0.45 at EP. NIC_AP was independently affected by VFA (β = 0.362, p < 0.001), smoking (β = −0.240, p = 0.001), and type-II diabetes (β = −0.449, p < 0.001); NIC_PP by VFA (β = −0.301, p = 0.017) and smoking (β = −0.291, p < 0.001); and NIC_EP by smoking (β = −0.154, p = 0.10) and alcohol consumption (β = −0.350, p < 0.001) with statistical power values over 0.81.

Conclusion

NIC values were consistent across institutions. Abdominal obesity, smoking, alcohol consumption, and diabetes are independent factors influencing pancreatic iodine uptake.

Clinical relevance statement

This study has provided reference normative values, influential factors and effective normalisation methods of pancreatic iodine uptake in multiphase dual-energy CT for future studies in this area as a new biological marker.

Key Points

Evaluation of pancreatic iodine uptake measured by dual-energy CT is a promising method for future studies.

Abdominal obesity, smoking, alcohol consumption, diabetes, and sex are independent factors influencing pancreatic iodine uptake.

Utility of normalised iodine concentration is necessary to ensure the consistency across different institutions.