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<p>To identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within ± 1 year) and Group 2 (prolonged transition to PsA, &gt; 1 year after PsO). Demographic, clinical, and laboratory characteristics, disease activity, and patient-reported outcomes were compared between groups. Logistic regression was employed to determine independent predictors of prolonged transition. Among 799 patients (mean age 46.8 ± 12.3 years), 237 (29.7%) had concurrent onset and 562 (70.3%) had a prolonged transition, with a mean PsO-to-PsA interval of 12.9 ± 9.6 years. Depression (<i>p</i> = 0.005) and fatigue levels (<i>p</i> = 0.011) were significantly higher in patients with prolonged transition to PsA. Multivariate analysis revealed that scalp psoriasis (OR = 7.162), nail psoriasis (OR = 3.270), family history of PsO (OR = 1.813), and enthesitis ever (OR = 2.187) were associated with prolonged transition. Conversely, family history of PsA (OR = 0.421) and older age at PsO onset (OR = 0.957) predicted shorter transition. Prolonged transition from PsO to PsA is influenced by distinct clinical and demographic factors. Scalp/nail psoriasis, family history of PsO, and enthesitis ever may signal higher risk for prolonged PsA onset. Recognizing these markers can support timely referral and intervention, minimizing diagnostic delay and improving long-term patient outcomes.</p>

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Factors influencing the transition time from psoriasis to psoriatic arthritis: a real-world multicenter analysis

  • 期刊论文

  • 发表日期：

    2025年9月9日

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  • Gamze Kılıç,
  • Erkan Kılıç,
  • İbrahim Tekeoğlu,
  • Betül Sargın,
  • Gizem Cengiz,
  • Nihan Cüzdan Balta,
  • Hakan Alkan,
  • Sevtap Acer Kasman,
  • Nilay Şahin,
  • Kevser Orhan,
  • İlknur Albayrak Gezer,
  • Dilek Keskin,
  • Cevriye Mülkoğlu,
  • Hatice Reşorlu,
  • Şebnem Ataman,
  • Ajda Bal,
  • Mehmet Tuncay Duruöz,
  • Okan Kücükakkaş,
  • Nesrin Şen,
  • Murat Toprak,
  • Ozan Volkan Yurdakul,
  • Meltem Alkan Melikoğlu,
  • Fikriye Figen Ayhan,
  • Merve Baykul,
  • Hatice Bodur,
  • Mustafa Çalış,
  • Erhan Çapkın,
  • Gül Devrimsel,
  • Sami Hizmetli,
  • Ayhan Kamanlı,
  • Yaşar Keskin,
  • Hilal Ecesoy,
  • Öznur Kutluk,
  • Ömer Faruk Şendur,
  • Sena Tolu,
  • Tiraje Tuncer,
  • Salih Özgöçmen,
  • Kemal Nas

摘要

To identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within ± 1 year) and Group 2 (prolonged transition to PsA, > 1 year after PsO). Demographic, clinical, and laboratory characteristics, disease activity, and patient-reported outcomes were compared between groups. Logistic regression was employed to determine independent predictors of prolonged transition. Among 799 patients (mean age 46.8 ± 12.3 years), 237 (29.7%) had concurrent onset and 562 (70.3%) had a prolonged transition, with a mean PsO-to-PsA interval of 12.9 ± 9.6 years. Depression (p = 0.005) and fatigue levels (p = 0.011) were significantly higher in patients with prolonged transition to PsA. Multivariate analysis revealed that scalp psoriasis (OR = 7.162), nail psoriasis (OR = 3.270), family history of PsO (OR = 1.813), and enthesitis ever (OR = 2.187) were associated with prolonged transition. Conversely, family history of PsA (OR = 0.421) and older age at PsO onset (OR = 0.957) predicted shorter transition. Prolonged transition from PsO to PsA is influenced by distinct clinical and demographic factors. Scalp/nail psoriasis, family history of PsO, and enthesitis ever may signal higher risk for prolonged PsA onset. Recognizing these markers can support timely referral and intervention, minimizing diagnostic delay and improving long-term patient outcomes.