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<p>Rheumatoid arthritis (RA) is a systemic inflammatory disorder frequently associated with sarcopenia, a gradual decline in skeletal muscle mass and strength. Hand sarcopenia in RA leads to functional deterioration and diminished quality of life. Although conventional methods, such as exercise and nutrition, are typically used, current evidence suggests that massage therapy may offer advantages through anti-inflammatory, circulatory, and anabolic pathways. This hypothesis-driven article proposes that targeted hand massage may alleviate sarcopenia in RA by enhancing local perfusion, modulating immunological responses, mitigating oxidative stress, and stimulating muscle-regenerative pathways. Experimental investigations in animals and humans have demonstrated that massage can activate mechanotransduction signaling, enhance muscle protein synthesis, stimulate satellite cell activity, and reduce inflammatory mediators, including tumor necrosis factor-alpha and interleukin-6. Moreover, enhancements in handgrip strength and muscle oxygenation have been documented after mechanical interventions. Small sample sizes, diverse methodologies, and the absence of standardized massage procedures limit the clinical validity of the data. Randomized controlled trials involving RA patients with compromised hand function and sarcopenia are necessary to explore this hypothesis. Standardized outcome measures, such as handgrip strength, disease activity scores, muscle tissue imaging, and inflammatory biomarkers, are required to assess efficacy. If verified, massage therapy may provide a non-invasive, low-risk complement to established care, potentially enhancing muscle function and quality of life in RA patients with sarcopenia.</p>

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Rheumatoid hand massage therapy to mitigate sarcopenia and improve patients’ quality of life: a hypothesis

  • 期刊论文

  • 发表日期：

    2025年7月17日

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  • Burhan Fatih Kocyigit,
  • Olena Zimba,
  • Marlen Yessirkepov,
  • Umida Khojakulova

摘要

Rheumatoid arthritis (RA) is a systemic inflammatory disorder frequently associated with sarcopenia, a gradual decline in skeletal muscle mass and strength. Hand sarcopenia in RA leads to functional deterioration and diminished quality of life. Although conventional methods, such as exercise and nutrition, are typically used, current evidence suggests that massage therapy may offer advantages through anti-inflammatory, circulatory, and anabolic pathways. This hypothesis-driven article proposes that targeted hand massage may alleviate sarcopenia in RA by enhancing local perfusion, modulating immunological responses, mitigating oxidative stress, and stimulating muscle-regenerative pathways. Experimental investigations in animals and humans have demonstrated that massage can activate mechanotransduction signaling, enhance muscle protein synthesis, stimulate satellite cell activity, and reduce inflammatory mediators, including tumor necrosis factor-alpha and interleukin-6. Moreover, enhancements in handgrip strength and muscle oxygenation have been documented after mechanical interventions. Small sample sizes, diverse methodologies, and the absence of standardized massage procedures limit the clinical validity of the data. Randomized controlled trials involving RA patients with compromised hand function and sarcopenia are necessary to explore this hypothesis. Standardized outcome measures, such as handgrip strength, disease activity scores, muscle tissue imaging, and inflammatory biomarkers, are required to assess efficacy. If verified, massage therapy may provide a non-invasive, low-risk complement to established care, potentially enhancing muscle function and quality of life in RA patients with sarcopenia.