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<p>Evaluating the predictive role of endothelial dysfunction in the development of vasculopathy-mediated complications in patients with limited cutaneous systemic sclerosis (lcSSc).&#xa0;38 patients with lcSSc who were naïve for vasculopathy-mediated complications, defined as absent pre-existing digital ulcers (DU), pulmonary hypertension (PH) and symptomatic atherosclerotic cardiovascular diseases, were prospectively observed during a 3-years follow-up period. At study enrolment, functional and laboratory parameters of endothelial dysfunction were assessed. Microvascular events, defined as the development of DU and PH, macrovascular events, defined as newly symptomatic atherosclerotic cardiovascular diseases, and clinical events, defined as additional interstitial lung disease (ILD), renal crisis and esophageal dysfunction, were recorded annually.&#xa0;33 patients (86.8%) completed all follow-up study visits. During the follow-up period, DU, PH, carotid and vertebral artery disease and ILD occurred in eight (24.2%), one (3.0%), one (3.0%) and two patients (6.1%), respectively, without recorded renal crisis and esophageal dysfunction. Number of pathologic FMD, NMD and/or PWV values was significantly associated with the development of clinical events (<i>p</i> = 0.035), but was not a significant predictor for microvascular events. Number of pathologic FMD, NMD and/or PWV values was a significant predictor for disease activity assessed by EUSTAR index ≥ 2.5 at last study visit (OR 5.47 [95% CI 1.01–29.03], <i>p</i> = 0.049).&#xa0;Distinct endothelial dysfunction may promote the development of disease complications and disease activity in patients with lcSSc.</p>

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Endothelial function and vascular events in patients with limited cutaneous systemic sclerosis (EFVELSS): a prospective observational study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月8日

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  • Philipp Jud,
  • Philipp Douschan,
  • Teresa Sassmann,
  • Günther Silbernagel,
  • Katharina Gütl,
  • Reinhard B. Raggam,
  • Peter Rief,
  • Leyla Schweiger,
  • Nikolaus John,
  • Gerald Seinost,
  • Vasile Foris,
  • Gabor Kovacs,
  • Thomas Gary,
  • Viktoria Nemecz,
  • Andreas Meinitzer,
  • Heimo Strohmaier,
  • Balazs Odler,
  • Florentine Moazedi-Fürst,
  • Marianne Brodmann,
  • Franz Hafner

摘要

Evaluating the predictive role of endothelial dysfunction in the development of vasculopathy-mediated complications in patients with limited cutaneous systemic sclerosis (lcSSc). 38 patients with lcSSc who were naïve for vasculopathy-mediated complications, defined as absent pre-existing digital ulcers (DU), pulmonary hypertension (PH) and symptomatic atherosclerotic cardiovascular diseases, were prospectively observed during a 3-years follow-up period. At study enrolment, functional and laboratory parameters of endothelial dysfunction were assessed. Microvascular events, defined as the development of DU and PH, macrovascular events, defined as newly symptomatic atherosclerotic cardiovascular diseases, and clinical events, defined as additional interstitial lung disease (ILD), renal crisis and esophageal dysfunction, were recorded annually. 33 patients (86.8%) completed all follow-up study visits. During the follow-up period, DU, PH, carotid and vertebral artery disease and ILD occurred in eight (24.2%), one (3.0%), one (3.0%) and two patients (6.1%), respectively, without recorded renal crisis and esophageal dysfunction. Number of pathologic FMD, NMD and/or PWV values was significantly associated with the development of clinical events (p = 0.035), but was not a significant predictor for microvascular events. Number of pathologic FMD, NMD and/or PWV values was a significant predictor for disease activity assessed by EUSTAR index ≥ 2.5 at last study visit (OR 5.47 [95% CI 1.01–29.03], p = 0.049). Distinct endothelial dysfunction may promote the development of disease complications and disease activity in patients with lcSSc.