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Background <p>Since neuropathology departments in Germany are mainly located only at university hospitals, brain sections are frequently performed by general pathologists. This article provides practical recommendations for a&#xa0;structured approach and highlights situations in which neuropathological consultation is advisable.</p> Methods <p>The recommendations are based on established procedures, current literature, and personal professional experience. They are intended as a&#xa0;practical guide rather than a&#xa0;formal guideline.</p> Results <p>Key steps for removal, fixation, and sectioning as well as interpretation of the findings are described. Hereby, the importance of clinical information and of a&#xa0;systematic assessment of macroscopic and histological changes is emphasized. Furthermore, typical situations are described in which neuropathological expertise is recommended.</p> Discussion <p>A&#xa0;structured brain section enhances the overall quality of the autopsy. It enables a&#xa0;valid integration of cerebral changes into a&#xa0;broader context. Close collaboration between pathology and neuropathology is essential and beneficial for both sides.</p>

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Hirnsektion in der Allgemeinpathologie

  • 期刊论文

  • 发表日期：

    2026年2月17日

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  • Friederike Liesche-Starnecker,
  • Zuzanna Mielewczyk,
  • Przemyslaw Grochowski,
  • Nicola Jungbäck,
  • Patrick Adam,
  • Bruno Märkl,
  • Jürgen Schlegel

摘要

Background

Since neuropathology departments in Germany are mainly located only at university hospitals, brain sections are frequently performed by general pathologists. This article provides practical recommendations for a structured approach and highlights situations in which neuropathological consultation is advisable.

Methods

The recommendations are based on established procedures, current literature, and personal professional experience. They are intended as a practical guide rather than a formal guideline.

Results

Key steps for removal, fixation, and sectioning as well as interpretation of the findings are described. Hereby, the importance of clinical information and of a systematic assessment of macroscopic and histological changes is emphasized. Furthermore, typical situations are described in which neuropathological expertise is recommended.

Discussion

A structured brain section enhances the overall quality of the autopsy. It enables a valid integration of cerebral changes into a broader context. Close collaboration between pathology and neuropathology is essential and beneficial for both sides.