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<p>Liver biopsies in unclear hepatitis are required to assess etiology together with the clinico-serological findings to differentiate comorbidities. In addition, inflammatory activity should be graded, extent of necrosis estimated, and the stage of fibrosis determined in order to estimate pre-existing parenchymal damage. In liver biopsies from patients with acute liver failure, drug-induced liver injury, most often in idiosyncrasy is most common. While a&#xa0;liver biopsy is required for the diagnosis of autoimmune hepatitis, the diagnosis of viral hepatitis&#xa0;A–D is usually made clinically and serologically. Yet, hepatitis&#xa0;E is often underestimated: in addition to acute hepatitis in immunocompetent patients, hepatitis E-virus (HEV) infection may also manifest with a&#xa0;fulminant course in patients with pre-existing liver cirrhosis and follow a&#xa0;chronic course in immunocompromised patients.</p>

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Hepatitisdiagnostik

  • 期刊论文

  • 发表日期：

    2025年9月18日

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  • Beate K. Straub,
  • Christian Labenz,
  • Achim Weber,
  • Uta Drebber

摘要

Liver biopsies in unclear hepatitis are required to assess etiology together with the clinico-serological findings to differentiate comorbidities. In addition, inflammatory activity should be graded, extent of necrosis estimated, and the stage of fibrosis determined in order to estimate pre-existing parenchymal damage. In liver biopsies from patients with acute liver failure, drug-induced liver injury, most often in idiosyncrasy is most common. While a liver biopsy is required for the diagnosis of autoimmune hepatitis, the diagnosis of viral hepatitis A–D is usually made clinically and serologically. Yet, hepatitis E is often underestimated: in addition to acute hepatitis in immunocompetent patients, hepatitis E-virus (HEV) infection may also manifest with a fulminant course in patients with pre-existing liver cirrhosis and follow a chronic course in immunocompromised patients.