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<p>Multifunctional nanocomposite blend hydrogels based on gelatin (GL), chitosan (CS), N-palmitoyl chitosan (PCS), graphene oxide (GO), and barium ferrite (BaFe) nanoparticles (NPs) were synthesized via electron beam irradiation. The application of these blend hydrogels as wound dressings by measuring the antimicrobial activity, coagulation properties, and in vitro wound healing scratch assay was investigated. The blend nanocomposites were characterized by gel content, swelling, FTIR spectroscopy, mechanical properties, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD), confirming successful cross-linking and NPs integration. The wound healing results indicated that the presence of GO NPs in the blends improved the antimicrobial activity and inhibited the growth of both Gram-negative and Gram-positive bacteria up to 90% and <i>Candida albicans</i> up to 87% compared to standard antibiotic discs. Moreover, in vitro scratch assays using HFB4 cells showed accelerated wound healing, with cell migration reaching 75% for the irradiated GL/CS/GO blend compared to 50.7% in the control. The synergistic effect of BaFe, GO, and N-palmitoyl chitosan significantly enhanced the hemostatic performance, reducing PTT to 20&#xa0;s, which demonstrates their high potential as bioactive dressings for rapid wound healing.</p>

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Fabrication of wound dressing based on biodegradable composites containing graphene oxide, chitosan, and barium ferrite nanoparticles by electron beam irradiation

  • 期刊论文

  • 发表日期：

    2026年7月10日

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  • Ayman Mahdy,
  • Reham H. Helal,
  • Yasser K. Abdel-Monem,
  • El-Sayed Elsherify,
  • Magdy M. H. Senna

摘要

Multifunctional nanocomposite blend hydrogels based on gelatin (GL), chitosan (CS), N-palmitoyl chitosan (PCS), graphene oxide (GO), and barium ferrite (BaFe) nanoparticles (NPs) were synthesized via electron beam irradiation. The application of these blend hydrogels as wound dressings by measuring the antimicrobial activity, coagulation properties, and in vitro wound healing scratch assay was investigated. The blend nanocomposites were characterized by gel content, swelling, FTIR spectroscopy, mechanical properties, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and X-ray diffraction (XRD), confirming successful cross-linking and NPs integration. The wound healing results indicated that the presence of GO NPs in the blends improved the antimicrobial activity and inhibited the growth of both Gram-negative and Gram-positive bacteria up to 90% and Candida albicans up to 87% compared to standard antibiotic discs. Moreover, in vitro scratch assays using HFB4 cells showed accelerated wound healing, with cell migration reaching 75% for the irradiated GL/CS/GO blend compared to 50.7% in the control. The synergistic effect of BaFe, GO, and N-palmitoyl chitosan significantly enhanced the hemostatic performance, reducing PTT to 20 s, which demonstrates their high potential as bioactive dressings for rapid wound healing.