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<p>Ester adducts of natural polymer rosin, obtained from pine tree, has been exploited as a nanocarrier for curcumin. Rosin ester adducts were synthesized using polyethylene glycol (PEG) and maleic anhydride (MA). The self-assembly behaviour of the PEGylated rosin ester was studied by fluorescence spectroscopy. Transmission electron microscopy (TEM) study revealed spherical and distinct core-shell morphology of the PEGylated rosin ester micelles with average diameter ˂100&#xa0;nm. Dynamic light scattering (DLS) study indicated average hydrodynamic diameter of the particles in the range of 131–210&#xa0;nm. The curcumin encapsulated PEGylated rosin esters initially showed spherical morphology while in dispersion but on aging and lyophilization the encapsulated curcumin revealed nanorod architectures. These rod-like curcumin nanostructures having diameter around 55–86&#xa0;nm and length more than 1&#xa0;μm, assembled to form beautiful hierarchical tassel-like bundles as revealed by the scanning electron microscopy <b>(</b>SEM) and TEM studies. The PEGylated rosin esters, curcumin and curcumin-encapsulated rosin ester nanocarriers were further characterized by fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC) studies. This work may open up a potential strategy to develop size and shape specific ideal food nanocarriers for improved therapeutic efficacy of curcumin.</p> Graphical abstract <p></p>

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Curcumin encapsulated rosin derivative nanocarriers forming self-assembled core-shell nanospheres and nanorods

  • 期刊论文

  • 发表日期：

    2026年7月10日

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  • Nirmala Devi

摘要

Ester adducts of natural polymer rosin, obtained from pine tree, has been exploited as a nanocarrier for curcumin. Rosin ester adducts were synthesized using polyethylene glycol (PEG) and maleic anhydride (MA). The self-assembly behaviour of the PEGylated rosin ester was studied by fluorescence spectroscopy. Transmission electron microscopy (TEM) study revealed spherical and distinct core-shell morphology of the PEGylated rosin ester micelles with average diameter ˂100 nm. Dynamic light scattering (DLS) study indicated average hydrodynamic diameter of the particles in the range of 131–210 nm. The curcumin encapsulated PEGylated rosin esters initially showed spherical morphology while in dispersion but on aging and lyophilization the encapsulated curcumin revealed nanorod architectures. These rod-like curcumin nanostructures having diameter around 55–86 nm and length more than 1 μm, assembled to form beautiful hierarchical tassel-like bundles as revealed by the scanning electron microscopy (SEM) and TEM studies. The PEGylated rosin esters, curcumin and curcumin-encapsulated rosin ester nanocarriers were further characterized by fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and gel permeation chromatography (GPC) studies. This work may open up a potential strategy to develop size and shape specific ideal food nanocarriers for improved therapeutic efficacy of curcumin.

Graphical abstract