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<p>In this study, a multifunctional gallic acid–incorporated silk fibroin–sodium alginate (SF–SA–GA) hydrogel was developed with optimized physicochemical and bioactive properties for wound healing. The hydrogel exhibited a balanced combination of mechanical strength, viscoelastic integrity, biodegradability, and moisture retention. Its interconnected porous structure facilitated moisture vapor transmission, supported GA incorporation, and enabled sustained biphasic release under both PBS and enzymatic conditions, while GA displayed dose-dependent antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.In vitro assays (CCK-8, Live/Dead staining, scratch tests) showed that the SF–SA–GA hydrogel supported fibroblast viability and promoted migration at an optimal GA concentration. In vivo, it accelerated full-thickness wound closure by enhancing neovascularization, stimulating epithelial regeneration, and promoting organized collagen deposition. These results suggest that the SF–SA–GA hydrogel represents a promising bioactive dressing for wound management.</p>

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Fabrication and characterization of gallic acid–incorporated silk fibroin/sodium alginate hydrogels for antibacterial and wound healing applications

  • 期刊论文

  • 发表日期：

    2026年5月26日

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  • Aihua Su,
  • Haiyang Zhang,
  • Xingliang Xiong,
  • Jiaming Wu,
  • Ding Tan,
  • Xinyu Liu,
  • Jun Zheng,
  • Qifeng Jiang

摘要

In this study, a multifunctional gallic acid–incorporated silk fibroin–sodium alginate (SF–SA–GA) hydrogel was developed with optimized physicochemical and bioactive properties for wound healing. The hydrogel exhibited a balanced combination of mechanical strength, viscoelastic integrity, biodegradability, and moisture retention. Its interconnected porous structure facilitated moisture vapor transmission, supported GA incorporation, and enabled sustained biphasic release under both PBS and enzymatic conditions, while GA displayed dose-dependent antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.In vitro assays (CCK-8, Live/Dead staining, scratch tests) showed that the SF–SA–GA hydrogel supported fibroblast viability and promoted migration at an optimal GA concentration. In vivo, it accelerated full-thickness wound closure by enhancing neovascularization, stimulating epithelial regeneration, and promoting organized collagen deposition. These results suggest that the SF–SA–GA hydrogel represents a promising bioactive dressing for wound management.