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<p>Mangiferin, a potent natural antioxidant, faces clinical constraints due to its extremely low water solubility and poor bioavailability. This study overcomes these limitations by fabricating a novel nanofiber delivery system via electrospinning, utilizing a poly (vinyl alcohol) (PVA) and chitosan (CS) matrix. By employing a strategic three-component solvent system, we achieved an exceptional mangiferin loading capacity of 6.7–12.5% (wt./wt.), surpassing its thermodynamic solubility limits by 5 to 10-fold. Optimized nanofibers exhibited a uniform morphology with an average diameter of 332 ± 84&#xa0;nm. Physicochemical analyses (FTIR, XRD, and DSC) and UV-Vis revealed that mangiferin was molecularly dispersed within the polymer matrix through robust intermolecular hydrogen bonding. The drug release behavior follows the Higuchi kinetic model (R<sup>2</sup> &gt; 0.95), indicative of a controlled Fickian diffusion mechanism. The 0.5% mangiferin loading demonstrated a better sustained-release profile (K<sub>H</sub>=3.1187%.min<sup>–2</sup>) compared to the 1.0% formulation, highlighting the necessity of sink conditions for predictable release kinetics. Mechanical characterization identified the 0.5% mangiferin formulation as optimal, providing a superior balance between tensile strength (5.0&#xa0;MPa) and functional flexibility, whereas stability monitoring via UV-Vis and FTIR confirmed the preservation of chemical integrity across various storage conditions. In vitro drug release studies in physiological conditions (pH 7.4) demonstrated a sustained release profile, reaching ~ 70% cumulative release within 7&#xa0;h at a fiber concentration of 0.2&#xa0;mg/mL. These findings establish the PVA–CS–mangiferin platform as a stable, mechanically robust, and efficient vehicle for the high-dose delivery of poorly soluble compounds, offering a promising strategy for advanced biomedical applications.</p> Graphical abstract <p></p>

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Electrospun poly(vinyl alcohol)-chitosan nanofibers integrated with mangiferin: fabrication and properties

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Thi Hong Nhung Vu,
  • Svetlana N. Morozkina,
  • Vera E. Sitnikova,
  • Yuliya Е. Generalova,
  • Quang Sang Nguyen,
  • Mayya V. Uspenskaya

摘要

Mangiferin, a potent natural antioxidant, faces clinical constraints due to its extremely low water solubility and poor bioavailability. This study overcomes these limitations by fabricating a novel nanofiber delivery system via electrospinning, utilizing a poly (vinyl alcohol) (PVA) and chitosan (CS) matrix. By employing a strategic three-component solvent system, we achieved an exceptional mangiferin loading capacity of 6.7–12.5% (wt./wt.), surpassing its thermodynamic solubility limits by 5 to 10-fold. Optimized nanofibers exhibited a uniform morphology with an average diameter of 332 ± 84 nm. Physicochemical analyses (FTIR, XRD, and DSC) and UV-Vis revealed that mangiferin was molecularly dispersed within the polymer matrix through robust intermolecular hydrogen bonding. The drug release behavior follows the Higuchi kinetic model (R2 > 0.95), indicative of a controlled Fickian diffusion mechanism. The 0.5% mangiferin loading demonstrated a better sustained-release profile (KH=3.1187%.min–2) compared to the 1.0% formulation, highlighting the necessity of sink conditions for predictable release kinetics. Mechanical characterization identified the 0.5% mangiferin formulation as optimal, providing a superior balance between tensile strength (5.0 MPa) and functional flexibility, whereas stability monitoring via UV-Vis and FTIR confirmed the preservation of chemical integrity across various storage conditions. In vitro drug release studies in physiological conditions (pH 7.4) demonstrated a sustained release profile, reaching ~ 70% cumulative release within 7 h at a fiber concentration of 0.2 mg/mL. These findings establish the PVA–CS–mangiferin platform as a stable, mechanically robust, and efficient vehicle for the high-dose delivery of poorly soluble compounds, offering a promising strategy for advanced biomedical applications.

Graphical abstract