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<p>The design of multifunctional biomaterials with intrinsic antibacterial properties and external stimuli-responsiveness is highly desirable for preventing medical device-associated infections, including catheter-related bloodstream infections and implant-associated bacterial colonization. In this work, composite films based on poly(vinyl alcohol) (PVA), gellan gum (GG), and polydopamine (PDA) were fabricated via a simple one-pot approach without additional crosslinkers or post-processing steps, through the in situ bulk polymerization of dopamine within a PVA/GG blend prior to casting. The films were comprehensively characterized using Fourier transform infrared spectroscopy, thermogravimetry, optical analysis, surface morphology by scanning electron spectroscopy and atomic force microscopy, contact angle measurements, X-ray photoelectron spectroscopy, and mechanical testing. The synthetic route favored catechol-rich PDA over quinone structures. PDA incorporation markedly influenced surface morphology, wettability, optical transmittance, and mechanical performance of composite films, properties that are critical for surface coating stability and durability. Notably, PVA/GG/PDA films exhibited strong bactericidal activity against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, two clinically relevant pathogens commonly associated with device-related infections. The antibacterial effect was significantly enhanced under near-infrared (NIR) irradiation via photothermal conversion. These results highlight the potential of these composite films as NIR-activated antibacterial surface coatings to prevent localized bacterial colonization and biofilm formation.</p>

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One-pot preparation of photothermal PVA/GG/PDA films for NIR-triggered antibacterial applications

  • 期刊论文

  • 发表日期：

    2026年3月24日

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  • Karla F. García Verdugo,
  • Lerma H. Chan Chan,
  • Brianda M. Salazar Salas,
  • Beatriz G. González González,
  • Abraham A. Leyva Verduzco,
  • Alexel J. Burgara Estrella,
  • Teresa del Castillo Castro

摘要

The design of multifunctional biomaterials with intrinsic antibacterial properties and external stimuli-responsiveness is highly desirable for preventing medical device-associated infections, including catheter-related bloodstream infections and implant-associated bacterial colonization. In this work, composite films based on poly(vinyl alcohol) (PVA), gellan gum (GG), and polydopamine (PDA) were fabricated via a simple one-pot approach without additional crosslinkers or post-processing steps, through the in situ bulk polymerization of dopamine within a PVA/GG blend prior to casting. The films were comprehensively characterized using Fourier transform infrared spectroscopy, thermogravimetry, optical analysis, surface morphology by scanning electron spectroscopy and atomic force microscopy, contact angle measurements, X-ray photoelectron spectroscopy, and mechanical testing. The synthetic route favored catechol-rich PDA over quinone structures. PDA incorporation markedly influenced surface morphology, wettability, optical transmittance, and mechanical performance of composite films, properties that are critical for surface coating stability and durability. Notably, PVA/GG/PDA films exhibited strong bactericidal activity against Escherichia coli and Staphylococcus aureus, two clinically relevant pathogens commonly associated with device-related infections. The antibacterial effect was significantly enhanced under near-infrared (NIR) irradiation via photothermal conversion. These results highlight the potential of these composite films as NIR-activated antibacterial surface coatings to prevent localized bacterial colonization and biofilm formation.