Scholarlink

<p>Non-small cell lung cancer (NSCLC) requires therapeutic strategies that combine effective drug delivery, molecular pathway regulation, and compatibility with the complex biochemical environment encountered during treatment. In this study, a multifunctional nano-platform (THN-1@compound 1@rutin) was constructed by integrating the natural flavonoid rutin with a microbial-derived THN-1 scaffold and a quinoline-based coordination component. Structural characterization by PXRD, FT-IR, and TGA confirmed the formation, stability, and crystallinity of the composite. Fluorescence investigations revealed strong solvent-dependent photoluminescence behavior, with water providing the highest emission intensity. The composite further exhibited exceptional selectivity and sensitivity toward the nitrofuran antibiotics NFX and NFT, with quenching efficiencies approaching complete signal suppression, low detection limits (0.323 ppm for NFX and 0.590 ppm for NFT), and excellent recyclability over multiple sensing cycles. Biological assays demonstrated that the nano-formulated rutin significantly improved anti-proliferative activity against A549 NSCLC cells compared with free rutin. The composite also induced a more pronounced regulation of RUNX3, a key tumor-suppressive transcription factor in NSCLC, indicating enhanced mechanistic efficacy. Collectively, the THN-1@compound 1@rutin system functions as both a sensitive fluorescence sensor for nitrofuran antibiotics and an improved therapeutic delivery platform, offering a dual-function approach with potential utility in NSCLC treatment and clinical monitoring.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Fluorescent naphthoquinone–terpenoid metabolites from marine streptomyces B9173 as rutin carriers for antibiotic detection and anti-NSCLC activity

  • 期刊论文

  • 发表日期：

    2026年3月26日

查看全文
  • Binhua Jiang,
  • Rusong Li,
  • Gaopeng Zhang

摘要

Non-small cell lung cancer (NSCLC) requires therapeutic strategies that combine effective drug delivery, molecular pathway regulation, and compatibility with the complex biochemical environment encountered during treatment. In this study, a multifunctional nano-platform (THN-1@compound 1@rutin) was constructed by integrating the natural flavonoid rutin with a microbial-derived THN-1 scaffold and a quinoline-based coordination component. Structural characterization by PXRD, FT-IR, and TGA confirmed the formation, stability, and crystallinity of the composite. Fluorescence investigations revealed strong solvent-dependent photoluminescence behavior, with water providing the highest emission intensity. The composite further exhibited exceptional selectivity and sensitivity toward the nitrofuran antibiotics NFX and NFT, with quenching efficiencies approaching complete signal suppression, low detection limits (0.323 ppm for NFX and 0.590 ppm for NFT), and excellent recyclability over multiple sensing cycles. Biological assays demonstrated that the nano-formulated rutin significantly improved anti-proliferative activity against A549 NSCLC cells compared with free rutin. The composite also induced a more pronounced regulation of RUNX3, a key tumor-suppressive transcription factor in NSCLC, indicating enhanced mechanistic efficacy. Collectively, the THN-1@compound 1@rutin system functions as both a sensitive fluorescence sensor for nitrofuran antibiotics and an improved therapeutic delivery platform, offering a dual-function approach with potential utility in NSCLC treatment and clinical monitoring.