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<p>Chitosan, the second most abundant polysaccharide after cellulose, is widely utilized in food, bioengineering, and cancer therapy due to its biodegradability, biocompatibility, bioactivity, and non-toxicity. In this work, chitosan nanoparticles (CH NPs) were synthesized from locally sourced crab shells of five different microparticle sizes 50&#xa0;μm, 60&#xa0;μm, 75&#xa0;μm, 90&#xa0;μm, and 105&#xa0;μm via the ionic gelation method, The structural, morphological and chemical composition of the CHNPs were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. SEM analysis showed that some microparticles tend to form agglomeration but 105&#xa0;μm precursor produced nanoparticles in the size range of 90–100&#xa0;nm, as determined using Image J software. FTIR spectra exhibited absorption peaks between 3427 and 3417&#xa0;cm⁻¹ corresponding to hydroxyl (O-H) and amine (N-H) stretching vibrations of primary amines. Peaks at 2933–2352&#xa0;cm⁻¹ were attributed to alkyl (C-H) stretching, while those between 1875 and 1631&#xa0;cm⁻¹ indicated the presence of carbonyl (C = O) groups from acetate. The FTIR spectrum of the 105&#xa0;μm-derived chitosan nanoparticles displayed a broad medium peak associated with amine (N-H) functional groups, and the degree of deacetylation (%DD) was calculated as 70%. These findings suggest that chitosan nanoparticles obtained under these conditions possess structural and chemical features that make them suitable for further exploration in biomedical applications, including drug delivery system.</p>

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Isolation and characterization of chitosan nanoparticles from different microparticle sizes of powdered crab shells for an improved drug delivery system

  • 期刊论文

  • 发表日期：

    2026年3月30日

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  • S. S. Oluyamo,
  • L. O. Akinboyewa,
  • O. I. Olusola,
  • A. F. Afolabi,
  • M. A. Adekoya

摘要

Chitosan, the second most abundant polysaccharide after cellulose, is widely utilized in food, bioengineering, and cancer therapy due to its biodegradability, biocompatibility, bioactivity, and non-toxicity. In this work, chitosan nanoparticles (CH NPs) were synthesized from locally sourced crab shells of five different microparticle sizes 50 μm, 60 μm, 75 μm, 90 μm, and 105 μm via the ionic gelation method, The structural, morphological and chemical composition of the CHNPs were characterized using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. SEM analysis showed that some microparticles tend to form agglomeration but 105 μm precursor produced nanoparticles in the size range of 90–100 nm, as determined using Image J software. FTIR spectra exhibited absorption peaks between 3427 and 3417 cm⁻¹ corresponding to hydroxyl (O-H) and amine (N-H) stretching vibrations of primary amines. Peaks at 2933–2352 cm⁻¹ were attributed to alkyl (C-H) stretching, while those between 1875 and 1631 cm⁻¹ indicated the presence of carbonyl (C = O) groups from acetate. The FTIR spectrum of the 105 μm-derived chitosan nanoparticles displayed a broad medium peak associated with amine (N-H) functional groups, and the degree of deacetylation (%DD) was calculated as 70%. These findings suggest that chitosan nanoparticles obtained under these conditions possess structural and chemical features that make them suitable for further exploration in biomedical applications, including drug delivery system.