<p>Infectious diseases are prevalent and frequent diseases in the world, imposing significant expenses on human society and posing a risk to human health. Antibiotics; are one of the most used treatments for infectious disease. However; the widespread incorrect use of antibiotics today, particularly in personal therapy, severely upsets the equilibrium of microorganisms in the environment and human bodies. The aim of this study is to explore and evaluate the antibacterial properties of mesoporous silica nanoparticles (MSNPs) that incorporate plant extracts from <i>Dermena</i> (<i>Artemisia aucheri</i>) and <i>Calpura</i> (<i>Teucrium polium</i>), with or without silver nitrate. The research seeks to develop an alternative antibacterial treatment to combat the increasing prevalence of infectious diseases, particularly those caused by bacteria resistant to conventional antibiotics. By combining plant extracts with mesoporous silica nanoparticles and silver nitrate, the study aims to enhance the antibacterial efficacy and provide a potential solution to the rising issue of antibiotic resistance. The study also investigates the synthesis, loading capacity, release behavior, and antimicrobial effectiveness of these nanoparticles, particularly against <i>Salmonella typhimurium</i>, demonstrating their potential as an antimicrobial agent. To; synthesize mesoporous silica, a TEOS silicate precursor and a CTAB molecular template were utilized. Following this, the silica nanoparticles were loaded with either plant extracts alone (MSNP1) or in coporation with silver nitrate (MSNP2). The SEM demonstrated the presence of spherical nanoparticles with a smooth surface. Also, TEM analysis show a clear signs of the porous characteristics of the nanoparticles. BET analysis, yielding values of approximately 0.93 cm³ g^− 1 and 682.6 m³ g^− 1 for unloaded nanoparticles, and 0.551 cm³ g^− 1 and 470.9 m²g^− 1 for loaded nanoparticles, respectively. The loading content (PLC) and encapsulation efficacy (PEE) of MSNP nanoparticles with plant-mixed extract demonstrate 21.53% and 25.9%, respectively. The release patterns of the loaded nanoparticles described by the Higuchi and first-order kinetics models. Finally, utilizing MSNP2, a mixture of plant extracts and silver nitrate, shows remarkable antimicrobial properties against <i>Salmonella typhimurium</i>. The zone of inhibition achieved a maximum diameter of 27&#xa0;cm, indicating the inhibition of bacterial growth. The minimum inhibitory concentration (MIC) was determined to be 20&#xa0;mg/mL, while the minimum bactericidal concentration (MBC) was found to be 25&#xa0;mg/mL.</p>