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<p>Bacterial cellulose (BC), a biodegradable and biocompatible material, has emerged as a promising wound dressing due to its excellent properties. <i>Moringa oleifera</i> (MO) and <i>Melastoma malabathricum</i> (MM) are traditional herbs rich in antioxidant, anti-inflammatory and antibacterial properties that are beneficial for rapid wound healing, while silver nanoparticles (Ag) is a highly effective antiseptic that is commonly used in medicine. In this study, BC formulated with Ag, MO and MM leaf extracts were characterized by using FTIR, XRD and FESEM-EDX. The water holding capacity, water retention rate and antibacterial activities of BC composites were also evaluated. Based on obtained results, incorporation of MO and MM enhanced the water holding capacity of BC without significantly altering its water retention rate. FTIR analysis confirmed the purity of BC and its crystallinity index was slightly increased in presence of MO, MM and Ag. FESEM-EDX imaging revealed deposition of MO, MM and Ag on the BC matrix. The antibacterial activities of BC composites varied against gram-positive and gram-negative bacteria. Nonetheless, these preliminary findings suggested that BC composites formulated with MO, MM and Ag may hold potential as sustainable wound dressings; however, further comprehensive studies are needed to validate their effectiveness. </p> Graphical Abstract <p></p>

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Preliminary evaluation of bacterial cellulose formulated with active ingredients of Moringa oleifera and Melastoma malabathricum leaf extracts for wound healing application

  • 期刊论文

  • 发表日期：

    2026年1月19日

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  • Nurul Nadiah Zulkarnain,
  • Imieda Vincent,
  • Norliza Abd. Rahman,
  • Jarinah Mohd Ali,
  • Mazlina Mohd Said,
  • Mashitoh Yaacob,
  • Kar Keng Lim

摘要

Bacterial cellulose (BC), a biodegradable and biocompatible material, has emerged as a promising wound dressing due to its excellent properties. Moringa oleifera (MO) and Melastoma malabathricum (MM) are traditional herbs rich in antioxidant, anti-inflammatory and antibacterial properties that are beneficial for rapid wound healing, while silver nanoparticles (Ag) is a highly effective antiseptic that is commonly used in medicine. In this study, BC formulated with Ag, MO and MM leaf extracts were characterized by using FTIR, XRD and FESEM-EDX. The water holding capacity, water retention rate and antibacterial activities of BC composites were also evaluated. Based on obtained results, incorporation of MO and MM enhanced the water holding capacity of BC without significantly altering its water retention rate. FTIR analysis confirmed the purity of BC and its crystallinity index was slightly increased in presence of MO, MM and Ag. FESEM-EDX imaging revealed deposition of MO, MM and Ag on the BC matrix. The antibacterial activities of BC composites varied against gram-positive and gram-negative bacteria. Nonetheless, these preliminary findings suggested that BC composites formulated with MO, MM and Ag may hold potential as sustainable wound dressings; however, further comprehensive studies are needed to validate their effectiveness.

Graphical Abstract