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<p>Hydrogels were synthesized via ionic crosslinking between chitosan&#xa0;(CS), a cationic polymer, and the anionic polymers sodium polyaspartate&#xa0;(NaPAsp), and alginate&#xa0;(AG), using the semi-dissolution/acidification/sol–gel transition method. The resulting pH-responsive CS/NaPAsp/AG hydrogel exhibits an average pore diameter of 200–300&#xa0;µm and a water absorption capacity ranging from 900 to 2000%. FTIR, XRD, and TGA analyses confirmed the formation of a polyelectrolyte network and SEM images showed a highly porous structure whose morphology varied with pH. Rheological studies revealed gel-like behavior and structural integrity over a wide pH range. CS-<i>g</i>-OA micelles exhibited spherical morphology and efficiently encapsulated coumarin-6 ( ~ 30%), employed as a hydrophobic fluorophore,&#xa0;while the hydrogel loaded with the micellar system achieved higher flourophore encapsulation efficiency ( ~ 53%), indicating synergistic retention of hydrophobic cargo. These properties suggest the hydrogel is well-suited for encapsulating and transporting coumarin derivatives and other hydrophobic drugs.</p>

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A pH-responsive chitosan/sodium polyaspartate/alginate hydrogel platform for coumarin-6 encapsulation

  • 期刊论文

  • 发表日期：

    2026年1月8日

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  • Carmen Luz Zegarra-Urquia,
  • Alfredo Angeles-Boza,
  • Julio Santiago-Contreras,
  • Daoning Zhang,
  • Erasto Armando Zaragoza-Contreras

摘要

Hydrogels were synthesized via ionic crosslinking between chitosan (CS), a cationic polymer, and the anionic polymers sodium polyaspartate (NaPAsp), and alginate (AG), using the semi-dissolution/acidification/sol–gel transition method. The resulting pH-responsive CS/NaPAsp/AG hydrogel exhibits an average pore diameter of 200–300 µm and a water absorption capacity ranging from 900 to 2000%. FTIR, XRD, and TGA analyses confirmed the formation of a polyelectrolyte network and SEM images showed a highly porous structure whose morphology varied with pH. Rheological studies revealed gel-like behavior and structural integrity over a wide pH range. CS-g-OA micelles exhibited spherical morphology and efficiently encapsulated coumarin-6 ( ~ 30%), employed as a hydrophobic fluorophore, while the hydrogel loaded with the micellar system achieved higher flourophore encapsulation efficiency ( ~ 53%), indicating synergistic retention of hydrophobic cargo. These properties suggest the hydrogel is well-suited for encapsulating and transporting coumarin derivatives and other hydrophobic drugs.