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<p>The current study describes the preparation and characterization of a new curcumin-loaded chitosan/silk fibroin/α-Fe₂O₃ nanocomposite (Cs-SF-Fe₂O₃-Cur) for the selective delivery of curcumin to breast cancer cells. The nanocomposite exhibited a hydrodynamic size of 301&#xa0;nm, a zeta potential of 40 mV, and an encapsulation efficiency of 87%. The drug release assay showed a pH-sensitive release profile of 82% at pH 5.4, simulating the tumor microenvironment. In vitro cytotoxicity assays on MCF-7 breast cancer cells showed that, compared to free curcumin, the cell viability remarkably decreased to 44%. In comparison, apoptotic rates reached up to 30% in the treatment of the nanocomposite. Therefore, the present results confirm Cs-SF-Fe₂O₃-Cur as a potential drug delivery system, which may enhance the stability, bioavailability, and thus the therapeutic efficiency of curcumin.</p>

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Drug release and kinetic studies of curcumin-loaded chitosan/silk fibroin/α-Fe2O3 pH-sensitive nanocomposites

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Ali Koulivand,
  • Hadi Tabesh,
  • Fatemeh Yazdian,
  • Mehrab Pourmadadi,
  • Reza Abbasi,
  • Abbas Rahdar,
  • M. Ali Aboudzadeh

摘要

The current study describes the preparation and characterization of a new curcumin-loaded chitosan/silk fibroin/α-Fe₂O₃ nanocomposite (Cs-SF-Fe₂O₃-Cur) for the selective delivery of curcumin to breast cancer cells. The nanocomposite exhibited a hydrodynamic size of 301 nm, a zeta potential of 40 mV, and an encapsulation efficiency of 87%. The drug release assay showed a pH-sensitive release profile of 82% at pH 5.4, simulating the tumor microenvironment. In vitro cytotoxicity assays on MCF-7 breast cancer cells showed that, compared to free curcumin, the cell viability remarkably decreased to 44%. In comparison, apoptotic rates reached up to 30% in the treatment of the nanocomposite. Therefore, the present results confirm Cs-SF-Fe₂O₃-Cur as a potential drug delivery system, which may enhance the stability, bioavailability, and thus the therapeutic efficiency of curcumin.