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<p>This study investigates a pH-responsive hydrogel for the targeted delivery of mesalamine to treat colitis. The hydrogel exhibited excellent pH-dependent swelling and drug release behaviour, releasing approximately 80% of cumulative mesalamine in colonic (pH 7.4) conditions over 48&#xa0;h. In vitro, drug release from the pH-responsive hydrogel in response to extracellular acidity was demonstrated. In preclinical in vivo studies, rats treated with the pH-responsive hydrogel had significantly lower Disease Activity Index (DAI) scores (1.5 ± 0.3) than disease controls (6.2 ± 0.5). Histopathological analysis of colon tissue showed reduced epithelial erosion and inflammation. Biochemical assessments indicated decreased oxidative stress markers (MDA: 5.3 ± 0.8 nmol/g tissue). We also had restored antioxidant levels (GSH: 0.75 ± 0.05 µmol/g tissue). Proinflammatory cytokine levels in treated animals were reduced to less than 8 nmol/g tissue compared to elevated levels in the disease control group. These findings suggest that the developed pH-responsive hydrogel is a promising carrier for targeted mesalamine delivery in ulcerative colitis management.</p> Graphical Abstract <p></p>

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Design, optimization, and evaluation of a pH-sensitive hydrogel system for colon-targeted mesalamine delivery

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Ruchi Tiwari,
  • K. S. Keshava,
  • R. Senthil Prabhu,
  • Prasanthi Samathoti,
  • S. Manodhini Elakkiya,
  • Ram C. Dhakar,
  • Manish R. Bhise,
  • Pankaj Sharma

摘要

This study investigates a pH-responsive hydrogel for the targeted delivery of mesalamine to treat colitis. The hydrogel exhibited excellent pH-dependent swelling and drug release behaviour, releasing approximately 80% of cumulative mesalamine in colonic (pH 7.4) conditions over 48 h. In vitro, drug release from the pH-responsive hydrogel in response to extracellular acidity was demonstrated. In preclinical in vivo studies, rats treated with the pH-responsive hydrogel had significantly lower Disease Activity Index (DAI) scores (1.5 ± 0.3) than disease controls (6.2 ± 0.5). Histopathological analysis of colon tissue showed reduced epithelial erosion and inflammation. Biochemical assessments indicated decreased oxidative stress markers (MDA: 5.3 ± 0.8 nmol/g tissue). We also had restored antioxidant levels (GSH: 0.75 ± 0.05 µmol/g tissue). Proinflammatory cytokine levels in treated animals were reduced to less than 8 nmol/g tissue compared to elevated levels in the disease control group. These findings suggest that the developed pH-responsive hydrogel is a promising carrier for targeted mesalamine delivery in ulcerative colitis management.

Graphical Abstract