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<p>In this work, redox-responsive quaternized ionene macromonomer PK-Im and homopolymer PK-Ip with a high cationic charge were synthesized, and the effect of cerium compounds on their biological activity was studied. PK-Im was synthesized by epichlorohydrin and 1,3-bisdimethylaminopropan-2-ol polycondensation in dimethylaminopropyl methacrylamide presence in water (conversion 74%). PK-Ip was synthesized by PK-Im polymerization in the AIBN presence in nitrogen stream in DMSO medium at 70&#xa0;°C (conversion 90%). The critical aggregation concentration of PK-Ip was equal to 220&#xa0;mg/L. PK-Im and PK-Ip do not significantly affect the morphology and metabolic activity of NCTC clone 929 cells (viability not less than 90%). PK-Ip dose-dependently increased the specific activity of enzymes: (1) SOD by 72–75% with a decrease in MDA by 16–60%; (2) catalase – by 18–26%; (3) glucose-6-phosphate dehydrogenase – by 22% and 42%, (4) glutathione reductase – by 19%. The Ce(NO<sub>3</sub>)<sub>3</sub>, CeO<sub>2</sub> and PK-Ip combined effect significantly increased the enzyme activity by 1.5–2 times. Bactericidal (<i>E. coli, S. aureus</i>) and fungicidal activity (<i>P. variotii</i>) of both PK-Ip and its combination with Ce(NO<sub>3</sub>)<sub>3</sub> was revealed. The possibility of self-organization of PK-Ip and PK-Im in mixed monolayers with lecithin and cholesterol in the cerium presence/absence to form various polymer-lipid nanostructures was shown. Therefore, the PK-Ip and PK-Im combination, lipids and cerium compounds may be promising for the creation of nanosized drug delivery systems and wound dressings.</p> Graphical abstract <p></p>

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Cerium effect on biological properties of new redox-responsive ionene polymers, their self-assembly in mixed ‘lipid-quaternized ionene polymer’ monolayers

  • 期刊论文

  • 发表日期：

    2025年12月15日

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  • Nina Melnikova,
  • Olga Zamyshlyayeva,
  • Denis Kamorin,
  • Oleg Kazantsev,
  • Alexander Simagin,
  • Alexey Belikov,
  • Anna Soloveva,
  • Ekaterina Marasanova,
  • Elena Mitroshina,
  • Maria Vedunova

摘要

In this work, redox-responsive quaternized ionene macromonomer PK-Im and homopolymer PK-Ip with a high cationic charge were synthesized, and the effect of cerium compounds on their biological activity was studied. PK-Im was synthesized by epichlorohydrin and 1,3-bisdimethylaminopropan-2-ol polycondensation in dimethylaminopropyl methacrylamide presence in water (conversion 74%). PK-Ip was synthesized by PK-Im polymerization in the AIBN presence in nitrogen stream in DMSO medium at 70 °C (conversion 90%). The critical aggregation concentration of PK-Ip was equal to 220 mg/L. PK-Im and PK-Ip do not significantly affect the morphology and metabolic activity of NCTC clone 929 cells (viability not less than 90%). PK-Ip dose-dependently increased the specific activity of enzymes: (1) SOD by 72–75% with a decrease in MDA by 16–60%; (2) catalase – by 18–26%; (3) glucose-6-phosphate dehydrogenase – by 22% and 42%, (4) glutathione reductase – by 19%. The Ce(NO3)3, CeO2 and PK-Ip combined effect significantly increased the enzyme activity by 1.5–2 times. Bactericidal (E. coli, S. aureus) and fungicidal activity (P. variotii) of both PK-Ip and its combination with Ce(NO3)3 was revealed. The possibility of self-organization of PK-Ip and PK-Im in mixed monolayers with lecithin and cholesterol in the cerium presence/absence to form various polymer-lipid nanostructures was shown. Therefore, the PK-Ip and PK-Im combination, lipids and cerium compounds may be promising for the creation of nanosized drug delivery systems and wound dressings.

Graphical abstract